Technology Process of 2,3-dihydro-5,6,8,9-tetramethoxy-1-benzylindeno<1,2,3-ij>isoquinolinium chloride
There total 9 articles about 2,3-dihydro-5,6,8,9-tetramethoxy-1-benzylindeno<1,2,3-ij>isoquinolinium chloride which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
trichlorophosphate;
In
toluene;
for 4h;
Heating;
- Guidance literature:
-
Multi-step reaction with 10 steps
1: SOCl2 / 24 h / Ambient temperature
2: CH2Cl2 / 1 h / 0 °C
3: 93 percent / SOCl2
4: 92 percent / tetrahydrofuran / 1.) reflux, 10 min, 2.) room temperature, 20 h
5: 44 percent / n-BuLi / hexane; tetrahydrofuran / 3 h / -10 - -5 °C
6: 79 percent / 3M HCl / H2O / 0.33 h / Heating
7: 88 percent / benzylamine / 24 h / 120 - 125 °C
8: 97 percent / pyridine
9: 71 percent / NaH / tetrahydrofuran / Heating
10: 92 percent / POCl3 / toluene / 4 h / Heating
With
pyridine; hydrogenchloride; n-butyllithium; thionyl chloride; sodium hydride; benzylamine; trichlorophosphate;
In
tetrahydrofuran; hexane; dichloromethane; water; toluene;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 92 percent / tetrahydrofuran / 1.) reflux, 10 min, 2.) room temperature, 20 h
2: 44 percent / n-BuLi / hexane; tetrahydrofuran / 3 h / -10 - -5 °C
3: 79 percent / 3M HCl / H2O / 0.33 h / Heating
4: 88 percent / benzylamine / 24 h / 120 - 125 °C
5: 97 percent / pyridine
6: 71 percent / NaH / tetrahydrofuran / Heating
7: 92 percent / POCl3 / toluene / 4 h / Heating
With
pyridine; hydrogenchloride; n-butyllithium; sodium hydride; benzylamine; trichlorophosphate;
In
tetrahydrofuran; hexane; water; toluene;
