85010-19-1Relevant academic research and scientific papers
An oxazoline based approach to (S)-gossypol
Meyers,Willemsen, Jeffrey J.
, p. 10493 - 10511 (2007/10/03)
(S)-Gossypol (S)-1, a yellow pigment of cottonseed, has been accessed by a total asymmetric synthesis. The sequence leading to (S)-gossypol (S)-1 was highlighted by four oxazoline mediated reactions, including coupling of ortho-(methoxy)aryloxazolines with Grignard reagents, butyllithium based ortho-lithiation of aryloxazolines, stereocontrolled Ullman couplings of bromonaphthyloxazolines, and ethoxyvinyllithium hexamethylphosphoric triamide complex based ortho-lithiation of aryloxazolines.
An asymmetric synthesis of (+)-apogossypol hexamethyl ether
Meyers,Willemsen, Jeffrey J.
, p. 791 - 792 (2007/10/03)
The first asymmetric synthesis of the gossypol backbone via a stereocontrolled oxazoline mediated 2,2' Ullmann coupling has been achieved.
Synthesis and dopaminergic binding of 2-aryldopamine analogues: Phenethylamines, 3-benzazepines, and 9-(aminomethyl)fluorenes
Ladd,Weinstock,Wise,Gessner,Sawyer,Flaim
, p. 1904 - 1912 (2007/10/02)
A series of 2-aryldopamine analogues were synthesized and evaluated for their effects on D1 and D2 dopamine receptors. The 2-phenyldopamine and 6-phenylbenzazepine analogues exhibited weak binding to both D1 and D2/s
Synthesis of indenoisoquinolines
Patel, Hemant A.,MacLean, David B.
, p. 7 - 13 (2007/10/02)
1-Methyl and 1-benzyl-1,2,3,10b-tetrahydro-5,6,8,9-tetramethoxyindenoisoquinoline have been synthesized from the corresponding 8-phenyl-3,4-dihydro-1(2H)isoquinolinones by treatment with POCl3 under Vilsmeier conditions followed the borohydride
