methyl N-(5-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)methoxy)-2-fluorobenzyl)-N-(methoxycarbonyl)glycinate

Base Information

Chemical Name:methyl N-(5-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)methoxy)-2-fluorobenzyl)-N-(methoxycarbonyl)glycinate
CAS No.:1000998-68-4
Molecular Formula:C₂₃H₂₂ClFN₂O₆
Molecular Weight:476.889
Hs Code.:

Synonyms:methyl N-(5-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)methoxy)-2-fluorobenzyl)-N-(methoxycarbonyl)glycinate

Suppliers and Price of methyl N-(5-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)methoxy)-2-fluorobenzyl)-N-(methoxycarbonyl)glycinate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl N-(5-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)methoxy)-2-fluorobenzyl)-N-(methoxycarbonyl)glycinate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl N-(5-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)methoxy)-2-fluorobenzyl)-N-(methoxycarbonyl)glycinate

There total 5 articles about methyl N-(5-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)methoxy)-2-fluorobenzyl)-N-(methoxycarbonyl)glycinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1000998-66-2
methyl 2-(5-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)methoxy)-2-fluorobenzylamino)acetate

: 79-22-1
methyl chloroformate

: 1000998-68-4
methyl N-(5-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)methoxy)-2-fluorobenzyl)-N-(methoxycarbonyl)glycinate

Guidance literature:: With sodium carbonate; In tetrahydrofuran; water; at 20 ℃; for 0.333333h; Product distribution / selectivity;

Reference yield: 91.0%

: 1000998-72-0
methyl N-(2-fluoro-5-hydroxybenzyl)-N-(methoxycarbonyl)glycinate

: 832076-92-3
4-(chloromethyl)-2-(4-chlorophenyl)-5-methyl-1,3-oxazole

: 1000998-68-4
methyl N-(5-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)methoxy)-2-fluorobenzyl)-N-(methoxycarbonyl)glycinate

Guidance literature:: With potassium carbonate; In acetonitrile; for 4h; Inert atmosphere; Heating;
DOI:10.1021/acsmedchemlett.6b00033

Reference yield:

: 105728-90-3
2-fluoro-5-methoxybenzaldehyde

: 1000998-68-4
methyl N-(5-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)methoxy)-2-fluorobenzyl)-N-(methoxycarbonyl)glycinate

Guidance literature:: Multi-step reaction with 4 steps

1.1: boron tribromide / dichloromethane / -78 - 0 °C

2.1: potassium carbonate / acetonitrile / 6 h / 80 °C / Inert atmosphere

3.1: triethylamine / methanol / 20 °C / Inert atmosphere

3.2: 1 h / -5 - 20 °C / Inert atmosphere

4.1: sodium carbonate / tetrahydrofuran; water / 0.33 h / 20 °C

With boron tribromide; sodium carbonate; potassium carbonate; triethylamine; In tetrahydrofuran; methanol; dichloromethane; water; acetonitrile;
DOI:10.1021/acsmedchemlett.6b00033