methyl 2-(5-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)methoxy)-2-fluorobenzylamino)acetate

Base Information

Chemical Name:methyl 2-(5-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)methoxy)-2-fluorobenzylamino)acetate
CAS No.:1000998-66-2
Molecular Formula:C₂₁H₂₀ClFN₂O₄
Molecular Weight:418.852
Hs Code.:

Synonyms:methyl 2-(5-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)methoxy)-2-fluorobenzylamino)acetate

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Chemical Property of methyl 2-(5-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)methoxy)-2-fluorobenzylamino)acetate

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Technology Process of methyl 2-(5-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)methoxy)-2-fluorobenzylamino)acetate

There total 3 articles about methyl 2-(5-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)methoxy)-2-fluorobenzylamino)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1000998-64-0
5-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)methoxy)-2-fluorobenzaldehyde

: 5680-79-5,883886-67-7
glycine ethyl ester hydrochloride

: 1000998-66-2
methyl 2-(5-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)methoxy)-2-fluorobenzylamino)acetate

Guidance literature:: 5-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)methoxy)-2-fluorobenzaldehyde; glycine ethyl ester hydrochloride; With triethylamine; In methanol; at 20 ℃; Inert atmosphere;

With sodium tetrahydroborate; In methanol; at -5 - 20 ℃; for 1h; Inert atmosphere;
DOI:10.1021/acsmedchemlett.6b00033

Reference yield:

: 105728-90-3
2-fluoro-5-methoxybenzaldehyde

: 1000998-66-2
methyl 2-(5-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)methoxy)-2-fluorobenzylamino)acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: boron tribromide / dichloromethane / -78 - 0 °C

2.1: potassium carbonate / acetonitrile / 6 h / 80 °C / Inert atmosphere

3.1: triethylamine / methanol / 20 °C / Inert atmosphere

3.2: 1 h / -5 - 20 °C / Inert atmosphere

With boron tribromide; potassium carbonate; triethylamine; In methanol; dichloromethane; acetonitrile;
DOI:10.1021/acsmedchemlett.6b00033

Reference yield:

: 103438-84-2
methyl 2-amino-3-(2-fluoro-5-hydroxyphenyl)propanoate

: 1000998-66-2
methyl 2-(5-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)methoxy)-2-fluorobenzylamino)acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / acetonitrile / 6 h / 80 °C / Inert atmosphere

2.1: triethylamine / methanol / 20 °C / Inert atmosphere

2.2: 1 h / -5 - 20 °C / Inert atmosphere

With potassium carbonate; triethylamine; In methanol; acetonitrile;
DOI:10.1021/acsmedchemlett.6b00033