ethyl 2-(ethyl(((4-methoxybenzyl)oxy)carbonyl)amino)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate

Base Information

• Chemical Name: ethyl 2-(ethyl(((4-methoxybenzyl)oxy)carbonyl)amino)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate
• CAS No.: 1315321-41-5
• Molecular Formula: C₂₂H₂₇NO₅S
• Molecular Weight: 417.526
• Mol file: 1315321-41-5.mol

Synonyms:ethyl 2-(ethyl(((4-methoxybenzyl)oxy)carbonyl)amino)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate

Chemical Property of ethyl 2-(ethyl(((4-methoxybenzyl)oxy)carbonyl)amino)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-(ethyl(((4-methoxybenzyl)oxy)carbonyl)amino)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate

There total 3 articles about ethyl 2-(ethyl(((4-methoxybenzyl)oxy)carbonyl)amino)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

diethyl sulfate (64-67-5) + ethyl 2-((((4-methoxybenzyl)oxy)carbonyl)amino)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (1315321-39-1) → ethyl 2-(ethyl(((4-methoxybenzyl)oxy)carbonyl)amino)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (1315321-41-5)

Guidance literature:

With tetra-(n-butyl)ammonium iodide; caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;

DOI:10.1039/c0ob01156h

Reference yield:

ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (4506-71-2) → ethyl 2-(ethyl(((4-methoxybenzyl)oxy)carbonyl)amino)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (1315321-41-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: tetra-(n-butyl)ammonium iodide; caesium carbonate / N,N-dimethyl-formamide / 1 h

1.2: 3.5 h

2.1: tetra-(n-butyl)ammonium iodide; caesium carbonate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

With tetra-(n-butyl)ammonium iodide; caesium carbonate; In N,N-dimethyl-formamide;

DOI:10.1039/c0ob01156h

Reference yield:

p-methoxybenzyl chloride (824-94-2) → ethyl 2-(ethyl(((4-methoxybenzyl)oxy)carbonyl)amino)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (1315321-41-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: tetra-(n-butyl)ammonium iodide; caesium carbonate / N,N-dimethyl-formamide / 1 h

1.2: 3.5 h

2.1: tetra-(n-butyl)ammonium iodide; caesium carbonate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

With tetra-(n-butyl)ammonium iodide; caesium carbonate; In N,N-dimethyl-formamide;

DOI:10.1039/c0ob01156h

upstream raw materials:

diethyl sulfate

ethyl 2-((((4-methoxybenzyl)oxy)carbonyl)amino)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate

ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate

p-methoxybenzyl chloride

Downstream raw materials:

(4-methoxyphenyl)-(2-methoxy-5-methylphenyl)methane

ethyl 2-(ethylamino)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate