Welcome to LookChem.com Sign In|Join Free


  • or


Post Buying Request

64-67-5 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

64-67-5 Usage

Chemical Properties

Diethyl sulfate is a colorless, oily liquid with a faint peppermint- like odor, which darkens with age (Budavari, 1996). It is miscible with alcohol and ether (O'Neil, 2006). At higher temperatures, DES rapidly decomposes into monoethyl sulfate and alcohol (NTP, 2011).


The primary use of diethyl sulfate is as a chemical intermediate (ethylating agent) in synthesis of ethyl derivatives of phenols, amines, and thiols; as an accelerator in the sulfation of ethylene; and in some sulfonation processes. It is used to manufacture dyes, pigments, carbonless paper, and textiles. It is an intermediate in the indirect hydration (strong acid) process for the preparation of synthetic ethanol from ethylene. Smaller quantities are used in household products, cosmetics, agricultural chemicals, pharmaceuticals, and laboratory reagents (IARC 1992, 1999, HSDB 2009). In 1966, it was used as a mutagen to create the Luther variety of barley (IARC 1974).


Diethyl sulfate can be used as a reactant for the synthesis of:Biologically active compounds such as bispyrazole, pyrazolopyrimidine and pyridine containing antipyrinyl moieties.N-substituted-2-styryl-4(3H)-quinazolinones.Ionic liquids with pyrrolidinium, piperidinium and morpholinium cations, having potential applications as electrolytes.It can also be used as an alkylating agent to synthesize 1-alkyl/aralkyl-2-(1-arylsufonylalkyl)benzimidazoles and an ionic liquid ethylmethylimidazole ethylsulfate ([EMIM][EtSO4].


ChEBI: Diethyl sulfate is the diethyl ester of sulfuric acid. It has a role as a carcinogenic agent, an apoptosis inducer, an alkylating agent and a mutagen.


Diethyl sulfate is produced from ethanol and sulfuric acid, from ethylene and sulfuric acid, or from diethyl ether and fuming sulfuric acid (Budavari, 1996).

General Description

Diethyl sulfate appears as a clear colorless liquid with a peppermint odor. Burns, though may be difficult to ignite. Corrosive to metals and tissue. It is a potent alkylating agent.

Air & Water Reactions

Highly flammable. Slowly reacts with water to form ethyl alcohol, a flammable liquid, and ethyl sulfate, with eventual conversion to sulfuric acid.

Reactivity Profile

The presence of moisture in a metal container of Diethyl sulfate caused the formation of sulfuric acid which reacts with the metal to release hydrogen which pressurized and exploded the container [Chem. Abst. 28:2908(1934)].

Health Hazard

May be fatal if inhaled, swallowed or absorbed through skin. Inhalation causes nausea and vomiting. Causes burns to skin and eyes. Ingestion may cause nausea, vomiting abdominal pain and collapse.

Safety Profile

Confirmed carcinogen with experimental carcinogenic and tumorigenic data. Poison by inhalation and subcutaneous routes. Moderately toxic by ingestion and sktn contact. A severe skin irritant. An experimental teratogen. Mutation data reported. Combustible when exposed to heat or flame; can react with oxidzing materials. Moisture causes liberation of H2SO4. Violent reaction with potassium tert-butoxide. Reacts violently with 3,8-dnitro-6-phenylphenanthridine + water. Reaction with iron + water forms explosive hydrogen gas. To fight fire, use alcohol foam, H2O foam, CO2, dry chemicals. When heated to decomposition it emits toxic fumes of SOx. See also SULFATES.


Diethyl sulfate is reasonably anticipated to be a human carcinogenbased on sufficient evidence of carcinogenicity from studies in experimental animals.

Purification Methods

Wash the ester with aqueous 3% Na2CO3 (to remove acidic material), then distilled water, dry (CaCl2), filter and distil it in a vacuum. It is an ethylating agent and blisters the skin. [Beilstein 1 IV 1236.]

Check Digit Verification of cas no

The CAS Registry Mumber 64-67-5 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 6 and 4 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 64-67:
55 % 10 = 5
So 64-67-5 is a valid CAS Registry Number.

64-67-5 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • TCI America

  • (D0525)  Diethyl Sulfate  >98.0%(GC)

  • 64-67-5

  • 25mL

  • 150.00CNY

  • Detail
  • TCI America

  • (D0525)  Diethyl Sulfate  >98.0%(GC)

  • 64-67-5

  • 500mL

  • 250.00CNY

  • Detail
  • Alfa Aesar

  • (L14291)  Diethyl sulfate, 98%   

  • 64-67-5

  • 100ml

  • 179.0CNY

  • Detail
  • Alfa Aesar

  • (L14291)  Diethyl sulfate, 98%   

  • 64-67-5

  • 500ml

  • 372.0CNY

  • Detail
  • Aldrich

  • (D100706)  Diethylsulfate  98%

  • 64-67-5

  • D100706-100G

  • 430.56CNY

  • Detail
  • Aldrich

  • (D100706)  Diethylsulfate  98%

  • 64-67-5

  • D100706-1KG

  • 558.09CNY

  • Detail
  • Aldrich

  • (D100706)  Diethylsulfate  98%

  • 64-67-5

  • D100706-2KG

  • 902.07CNY

  • Detail



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017


1.1 GHS Product identifier

Product name Diethyl sulfate

1.2 Other means of identification

Product number -
Other names Ethylsulpate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Diethyl sulfate is primarily used as an ethylating agent, and also as an accelerator in the sulfation of ethylene and in some sulfonations. Diethyl sulfate is also a chemical intermediate for ethyl derivatives of phenols, amines, and thiols, and as an alkylating agent.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:64-67-5 SDS

64-67-5Relevant articles and documents



, (1931)


Environmentally-friendly diethyl sulfate production process,


Paragraph 0031-0033, (2020/01/25)

The invention belongs to the field of chemical synthesis, and specially relates to an environmentally-friendly diethyl sulfate production process, which comprises: carrying out a reaction on a diethylsulfate intermediate (ethyl hydrogen sulfate or a mixture containing ethyl hydrogen sulfate) and sulfate or hydrochloride for 4-12 h at a temperature of 60-130 DEG C to generate a mixture of diethylsulfate and disulfate, cooling the mixture, dissolving with water, separating to obtain a disulfate solution and a diethyl sulfate crude product, and refining the diethyl sulfate crude product to obtain diethyl sulfate. According to the process of the invention, the reactants cannot be carbonized in the reaction process, the waste acid difficultly recycled is not generated, the product quality ishigh, the industrial production is easy to realize, and the process is an environmentally-friendly diethyl sulfate production process.

No-discharge atmospheric pressure chemical ionization mass spectrometry of ethyl glucuronide and ethyl sulfate

Favretto, Donata,Nalesso, Alessandro,Frison, Giampietro,Viel, Guido,Traldi, Pietro,Ferrara, Santo Davide

body text, p. 121 - 124 (2010/06/11)



Andrashchuk, N. P.,Moskvichev, Yu. A.,Shapiro, Yu. E.,Shutova, I. V.,Timoshenko, G. N.,Belyaeva, S. S.

, p. 1075 - 1079 (2007/10/02)

The composition of the products from the reaction of sulfur trioxide with dimethyl and diethyl sulfates and also with diethyl ether was investigated by 1H NMR spectroscopy.In addition to the main reaction leading to the formation of dialkyl polysulfates, in the case of the ethyl derivatives the side reaction involving sulfonation of the alkyl group at the β position is observed.This explains the preferred use of dimethyl sulfate in the syntheses of diaryl sulfones.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)


What can I do for you?
Get Best Price

Get Best Price for 64-67-5