triphenyl-[5-(4,4,5,5-tetra-methyl[1,3]dioxolan-2-yl)thiophen-2-yl-methyl]phosphanechloride

Base Information

Chemical Name:triphenyl-[5-(4,4,5,5-tetra-methyl[1,3]dioxolan-2-yl)thiophen-2-yl-methyl]phosphanechloride
CAS No.:1286685-13-9
Molecular Formula:C₃₀H₃₂O₂PS*Cl
Molecular Weight:523.076
Hs Code.:

Synonyms:triphenyl-[5-(4,4,5,5-tetra-methyl[1,3]dioxolan-2-yl)thiophen-2-yl-methyl]phosphanechloride

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Chemical Property of triphenyl-[5-(4,4,5,5-tetra-methyl[1,3]dioxolan-2-yl)thiophen-2-yl-methyl]phosphanechloride

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Technology Process of triphenyl-[5-(4,4,5,5-tetra-methyl[1,3]dioxolan-2-yl)thiophen-2-yl-methyl]phosphanechloride

There total 6 articles about triphenyl-[5-(4,4,5,5-tetra-methyl[1,3]dioxolan-2-yl)thiophen-2-yl-methyl]phosphanechloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 1286685-21-9
2-(5-chloromethylthiophen-2-yl)-4,4,5,5-tetramethyl[1,3]dioxolane

: 603-35-0
triphenylphosphine

: 1286685-13-9
triphenyl-[5-(4,4,5,5-tetra-methyl[1,3]dioxolan-2-yl)thiophen-2-yl-methyl]phosphanechloride

Guidance literature:: In tetrahydrofuran; for 72h; Inert atmosphere; Reflux;
DOI:10.1002/adfm.201001893

Reference yield:

: 98-03-3
thiophene-2-carbaldehyde

: 1286685-13-9
triphenyl-[5-(4,4,5,5-tetra-methyl[1,3]dioxolan-2-yl)thiophen-2-yl-methyl]phosphanechloride

Guidance literature:: Multi-step reaction with 5 steps

1: toluene-4-sulfonic acid / benzene / 72 h / Reflux

2: n-butyllithium / tetrahydrofuran; hexane / 5 h / 0 - 20 °C

3: sodium tetrahydroborate / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

4: thionyl chloride / 3 h / Reflux; Inert atmosphere

5: tetrahydrofuran / 72 h / Inert atmosphere; Reflux

With sodium tetrahydroborate; n-butyllithium; thionyl chloride; toluene-4-sulfonic acid; In tetrahydrofuran; hexane; benzene;
DOI:10.1002/adfm.201001893

Reference yield:

: 1286685-18-4
4,4,5,5-tetramethyl-2-thiophen-2-yl-[1,3]dioxalane

: 1286685-13-9
triphenyl-[5-(4,4,5,5-tetra-methyl[1,3]dioxolan-2-yl)thiophen-2-yl-methyl]phosphanechloride

Guidance literature:: Multi-step reaction with 4 steps

1: n-butyllithium / tetrahydrofuran; hexane / 5 h / 0 - 20 °C

2: sodium tetrahydroborate / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

3: thionyl chloride / 3 h / Reflux; Inert atmosphere

4: tetrahydrofuran / 72 h / Inert atmosphere; Reflux

With sodium tetrahydroborate; n-butyllithium; thionyl chloride; In tetrahydrofuran; hexane;
DOI:10.1002/adfm.201001893