(S)-(1-benzyl[1,2,3]triazol-4-yl)-[5-(4-bromophenyl)-3-methylisoxazol-4-yl]methanol

Base Information

Chemical Name:(S)-(1-benzyl[1,2,3]triazol-4-yl)-[5-(4-bromophenyl)-3-methylisoxazol-4-yl]methanol
CAS No.:1280732-84-4
Molecular Formula:C₂₀H₁₇BrN₄O₂
Molecular Weight:425.285
Hs Code.:

Synonyms:(S)-(1-benzyl[1,2,3]triazol-4-yl)-[5-(4-bromophenyl)-3-methylisoxazol-4-yl]methanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-(1-benzyl[1,2,3]triazol-4-yl)-[5-(4-bromophenyl)-3-methylisoxazol-4-yl]methanol

Chemical Property:

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Technology Process of (S)-(1-benzyl[1,2,3]triazol-4-yl)-[5-(4-bromophenyl)-3-methylisoxazol-4-yl]methanol

There total 6 articles about (S)-(1-benzyl[1,2,3]triazol-4-yl)-[5-(4-bromophenyl)-3-methylisoxazol-4-yl]methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1280732-85-5
(S)-1-[5-(4-bromo-phenyl)-3-methyl-isoxazol-4-yl]-prop-2-yn-1-ol

: 622-79-7
benzyl azide

: 1280732-84-4
(S)-(1-benzyl[1,2,3]triazol-4-yl)-[5-(4-bromophenyl)-3-methylisoxazol-4-yl]methanol

Guidance literature:: With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In water; dimethyl sulfoxide;

Reference yield:

: 85963-90-2
methyl 2-(4-bromobenzoyl)-3-oxo-butanoate

: 1280732-84-4
(S)-(1-benzyl[1,2,3]triazol-4-yl)-[5-(4-bromophenyl)-3-methylisoxazol-4-yl]methanol

Guidance literature:: Multi-step reaction with 6 steps

1: hydroxylamine hydrochloride; acetic acid / 1 h / 115 °C

2: lithium borohydride; ethanol / 60 °C

3: 4-methylmorpholine N-oxide / tetrapropylammonium perruthennate / dichloromethane

4: tetrahydrofuran / 1 h / -78 - 20 °C

5: Chiralcel AD / Resolution of racemate

6: sodium L-ascorbate; copper(ll) sulfate pentahydrate / water; dimethyl sulfoxide

With lithium borohydride; copper(ll) sulfate pentahydrate; ethanol; hydroxylamine hydrochloride; acetic acid; 4-methylmorpholine N-oxide; sodium L-ascorbate; tetrapropylammonium perruthennate; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide;

Reference yield:

: 1228689-61-9
methyl 5-(4-bromophenyl)-3-methylisoxazole-4-carboxylate

: 1280732-84-4
(S)-(1-benzyl[1,2,3]triazol-4-yl)-[5-(4-bromophenyl)-3-methylisoxazol-4-yl]methanol

Guidance literature:: Multi-step reaction with 5 steps

1: lithium borohydride; ethanol / 60 °C

2: 4-methylmorpholine N-oxide / tetrapropylammonium perruthennate / dichloromethane

3: tetrahydrofuran / 1 h / -78 - 20 °C

4: Chiralcel AD / Resolution of racemate

5: sodium L-ascorbate; copper(ll) sulfate pentahydrate / water; dimethyl sulfoxide

With lithium borohydride; copper(ll) sulfate pentahydrate; ethanol; 4-methylmorpholine N-oxide; sodium L-ascorbate; tetrapropylammonium perruthennate; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide;