{4-[1-methyl-5-((R)-1-phenylethoxycarbonylamino)-1H-pyrazol-4-yl]-phenyl}-acetic acid

Base Information

Chemical Name:{4-[1-methyl-5-((R)-1-phenylethoxycarbonylamino)-1H-pyrazol-4-yl]-phenyl}-acetic acid
CAS No.:1396006-96-4
Molecular Formula:C₂₁H₂₁N₃O₄
Molecular Weight:379.415
Hs Code.:

Synonyms:{4-[1-methyl-5-((R)-1-phenylethoxycarbonylamino)-1H-pyrazol-4-yl]-phenyl}-acetic acid

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Chemical Property of {4-[1-methyl-5-((R)-1-phenylethoxycarbonylamino)-1H-pyrazol-4-yl]-phenyl}-acetic acid

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Technology Process of {4-[1-methyl-5-((R)-1-phenylethoxycarbonylamino)-1H-pyrazol-4-yl]-phenyl}-acetic acid

There total 5 articles about {4-[1-methyl-5-((R)-1-phenylethoxycarbonylamino)-1H-pyrazol-4-yl]-phenyl}-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1396007-88-7
{4-[1-methyl-5-((R)-1-phenyl-ethoxycarbonylamino)-1H-pyrazol-4-yl]phenyl}acetic acid ethyl ester

: 1396006-96-4
{4-[1-methyl-5-((R)-1-phenylethoxycarbonylamino)-1H-pyrazol-4-yl]-phenyl}-acetic acid

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; water; at 60 ℃; for 6h; Inert atmosphere;
DOI:10.1021/jm301022v

Reference yield:

: 1517-69-7
(R)-1-phenylethanol

: 1396006-96-4
{4-[1-methyl-5-((R)-1-phenylethoxycarbonylamino)-1H-pyrazol-4-yl]-phenyl}-acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: diphenyl phosphoryl azide; triethylamine / toluene / 1 h / 80 °C / Inert atmosphere

2: potassium phosphate; palladium diacetate; XPhos / water; toluene / 4 h / 100 °C / Inert atmosphere; Sealed tube

3: lithium hydroxide / tetrahydrofuran; water / 6 h / 60 °C / Inert atmosphere

With potassium phosphate; diphenyl phosphoryl azide; palladium diacetate; triethylamine; lithium hydroxide; XPhos; In tetrahydrofuran; water; toluene; 1: |Curtius Rearrangement / 2: |Suzuki Coupling;
DOI:10.1021/jm301022v

Reference yield:

: 14062-25-0
Ethyl 4-bromophenylacetate

: 1396006-96-4
{4-[1-methyl-5-((R)-1-phenylethoxycarbonylamino)-1H-pyrazol-4-yl]-phenyl}-acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 1,4-dioxane / 3 h / 80 °C / Inert atmosphere; Sealed tube

2: potassium phosphate; palladium diacetate; XPhos / water; toluene / 4 h / 100 °C / Inert atmosphere; Sealed tube

3: lithium hydroxide / tetrahydrofuran; water / 6 h / 60 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; potassium acetate; palladium diacetate; lithium hydroxide; XPhos; In tetrahydrofuran; 1,4-dioxane; water; toluene; 2: |Suzuki Coupling;
DOI:10.1021/jm301022v