{4-[1-methyl-5-((R)-1-phenyl-ethoxycarbonylamino)-1H-pyrazol-4-yl]phenyl}acetic acid ethyl ester

Base Information

Chemical Name:{4-[1-methyl-5-((R)-1-phenyl-ethoxycarbonylamino)-1H-pyrazol-4-yl]phenyl}acetic acid ethyl ester
CAS No.:1396007-88-7
Molecular Formula:C₂₃H₂₅N₃O₄
Molecular Weight:407.469
Hs Code.:

Synonyms:{4-[1-methyl-5-((R)-1-phenyl-ethoxycarbonylamino)-1H-pyrazol-4-yl]phenyl}acetic acid ethyl ester

Suppliers and Price of {4-[1-methyl-5-((R)-1-phenyl-ethoxycarbonylamino)-1H-pyrazol-4-yl]phenyl}acetic acid ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of {4-[1-methyl-5-((R)-1-phenyl-ethoxycarbonylamino)-1H-pyrazol-4-yl]phenyl}acetic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of {4-[1-methyl-5-((R)-1-phenyl-ethoxycarbonylamino)-1H-pyrazol-4-yl]phenyl}acetic acid ethyl ester

There total 3 articles about {4-[1-methyl-5-((R)-1-phenyl-ethoxycarbonylamino)-1H-pyrazol-4-yl]phenyl}acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 859169-20-3
1-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-acetic acid ethyl ester

: 1396007-83-2
4-bromo-2-methyl-2H-pyrazol-3-yl-carbamic acid (R)-1-phenyl-ethyl ester

: 1396007-88-7
{4-[1-methyl-5-((R)-1-phenyl-ethoxycarbonylamino)-1H-pyrazol-4-yl]phenyl}acetic acid ethyl ester

Guidance literature:: With potassium phosphate; palladium diacetate; XPhos; In water; toluene; at 100 ℃; for 4h; Inert atmosphere; Sealed tube;
DOI:10.1021/jm301022v

Reference yield:

: 1517-69-7
(R)-1-phenylethanol

: 1396007-88-7
{4-[1-methyl-5-((R)-1-phenyl-ethoxycarbonylamino)-1H-pyrazol-4-yl]phenyl}acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: diphenyl phosphoryl azide; triethylamine / toluene / 1 h / 80 °C / Inert atmosphere

2: potassium phosphate; palladium diacetate; XPhos / water; toluene / 4 h / 100 °C / Inert atmosphere; Sealed tube

With potassium phosphate; diphenyl phosphoryl azide; palladium diacetate; triethylamine; XPhos; In water; toluene; 1: |Curtius Rearrangement / 2: |Suzuki Coupling;
DOI:10.1021/jm301022v

Reference yield:

: 14062-25-0
Ethyl 4-bromophenylacetate

: 1396007-88-7
{4-[1-methyl-5-((R)-1-phenyl-ethoxycarbonylamino)-1H-pyrazol-4-yl]phenyl}acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 1,4-dioxane / 3 h / 80 °C / Inert atmosphere; Sealed tube

2: potassium phosphate; palladium diacetate; XPhos / water; toluene / 4 h / 100 °C / Inert atmosphere; Sealed tube

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; potassium acetate; palladium diacetate; XPhos; In 1,4-dioxane; water; toluene; 2: |Suzuki Coupling;
DOI:10.1021/jm301022v