1-(2-chlorophenyl)-5-(4-chlorophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid

Base Information

Chemical Name:1-(2-chlorophenyl)-5-(4-chlorophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid
CAS No.:1034592-75-0
Molecular Formula:C₁₇H₁₂Cl₂N₂O₂
Molecular Weight:347.2
Hs Code.:

Synonyms:1-(2-chlorophenyl)-5-(4-chlorophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid

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Chemical Property of 1-(2-chlorophenyl)-5-(4-chlorophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid

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Technology Process of 1-(2-chlorophenyl)-5-(4-chlorophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid

There total 3 articles about 1-(2-chlorophenyl)-5-(4-chlorophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1012314-40-7
ethyl 4-(4-chlorophenyl)-3-methyl-4-oxydo-2-oxobuten-3-oate lithium salt

: 41052-75-9
o-chlorophenylhydrazine hydrochloride

: 1034592-75-0
1-(2-chlorophenyl)-5-(4-chlorophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid

Guidance literature:: With sulfuric acid; In ethanol; water; at 79 ℃; for 14h; Inert atmosphere;
DOI:10.1007/s00044-015-1346-4

Reference yield:

: 6285-05-8
4'-chloropropiophenone

: 1034592-75-0
1-(2-chlorophenyl)-5-(4-chlorophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hexamethyldisilazane / methyl cyclohexane / 2.5 h / 15 - 25 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: sulfuric acid / ethanol; water / 14 h / 79 °C / Inert atmosphere

With sulfuric acid; lithium hexamethyldisilazane; In ethanol; water; methyl cyclohexane;
DOI:10.1007/s00044-015-1346-4

Reference yield:

: 169544-41-6
4-(4-chlorophenyl)-3-methyl-2,4-dioxobutyric acid ethyl ester

: 1034592-75-0
1-(2-chlorophenyl)-5-(4-chlorophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: ethanol / 16 h / Reflux

2: water / tetrahydrofuran; methanol; water / 3 h / Reflux

With water; In tetrahydrofuran; methanol; ethanol; water;