1-(benzenesulfonyl)-2-iodo-pyrrolo[2,3-b]pyridin-5-amine hydrochloric acid salt

Base Information

Chemical Name:1-(benzenesulfonyl)-2-iodo-pyrrolo[2,3-b]pyridin-5-amine hydrochloric acid salt
CAS No.:1616388-14-7
Molecular Formula:C₁₃H₁₀IN₃O₂S*ClH
Molecular Weight:435.673
Hs Code.:

Synonyms:1-(benzenesulfonyl)-2-iodo-pyrrolo[2,3-b]pyridin-5-amine hydrochloric acid salt

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Chemical Property of 1-(benzenesulfonyl)-2-iodo-pyrrolo[2,3-b]pyridin-5-amine hydrochloric acid salt

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Technology Process of 1-(benzenesulfonyl)-2-iodo-pyrrolo[2,3-b]pyridin-5-amine hydrochloric acid salt

There total 5 articles about 1-(benzenesulfonyl)-2-iodo-pyrrolo[2,3-b]pyridin-5-amine hydrochloric acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1616387-99-5
tert-butyl (2-iodo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)carbamate

: 1616388-14-7
1-(benzenesulfonyl)-2-iodo-pyrrolo[2,3-b]pyridin-5-amine hydrochloric acid salt

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; acetonitrile; at 20 ℃; for 4h;

Reference yield:

: 183208-35-7
5-bromo-1H-pyrrolo[2,3-b]pyridine

: 1616388-14-7
1-(benzenesulfonyl)-2-iodo-pyrrolo[2,3-b]pyridin-5-amine hydrochloric acid salt

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 2.5 h / 0 °C

1.2: 20 °C

2.1: caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; palladium diacetate / 1,4-dioxane / Inert atmosphere; Reflux

3.1: tert.-butyl lithium / tetrahydrofuran / -78 - -20 °C

3.2: 20 °C

4.1: hydrogenchloride / 1,4-dioxane; acetonitrile / 4 h / 20 °C

With hydrogenchloride; tert.-butyl lithium; palladium diacetate; sodium hydride; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; acetonitrile; mineral oil;

Reference yield:

: 1001070-33-2
1-(benzenesulfonyl)-5-bromo-1H-pyrrolo[2,3-b]pyridine

: 1616388-14-7
1-(benzenesulfonyl)-2-iodo-pyrrolo[2,3-b]pyridin-5-amine hydrochloric acid salt

Guidance literature:: Multi-step reaction with 3 steps

1.1: caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; palladium diacetate / 1,4-dioxane / Inert atmosphere; Reflux

2.1: tert.-butyl lithium / tetrahydrofuran / -78 - -20 °C

2.2: 20 °C

3.1: hydrogenchloride / 1,4-dioxane; acetonitrile / 4 h / 20 °C

With hydrogenchloride; tert.-butyl lithium; palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; acetonitrile;