1-(2,4-dimethoxyphenyl)-N-{[4-fluoro-5-(2-fluoropyridin-3-yl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]methyl}-N-methylmethanamine

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Chemical Name:1-(2,4-dimethoxyphenyl)-N-{[4-fluoro-5-(2-fluoropyridin-3-yl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]methyl}-N-methylmethanamine
CAS No.:1055306-76-7
Molecular Formula:C₂₅H₂₄F₂N₄O₄S
Molecular Weight:514.553
Hs Code.:

Synonyms:1-(2,4-dimethoxyphenyl)-N-{[4-fluoro-5-(2-fluoropyridin-3-yl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]methyl}-N-methylmethanamine

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Chemical Property of 1-(2,4-dimethoxyphenyl)-N-{[4-fluoro-5-(2-fluoropyridin-3-yl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]methyl}-N-methylmethanamine

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Technology Process of 1-(2,4-dimethoxyphenyl)-N-{[4-fluoro-5-(2-fluoropyridin-3-yl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]methyl}-N-methylmethanamine

There total 8 articles about 1-(2,4-dimethoxyphenyl)-N-{[4-fluoro-5-(2-fluoropyridin-3-yl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]methyl}-N-methylmethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 16133-25-8
Pyridine-3-sulfonyl chloride

: 1-(2,4-dimethoxyphenyl)-N-{[4-fluoro-5-(2-fluoropyridin-3-yl)-1H-pyrrol-3-yl]methyl}-N-methylmethanamine

: 1055306-76-7
1-(2,4-dimethoxyphenyl)-N-{[4-fluoro-5-(2-fluoropyridin-3-yl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]methyl}-N-methylmethanamine

Guidance literature:: 1-(2,4-dimethoxyphenyl)-N-{[4-fluoro-5-(2-fluoropyridin-3-yl)-1H-pyrrol-3-yl]methyl}-N-methylmethanamine; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.166667h;

With 15-crown-5; In tetrahydrofuran; at 0 ℃; for 0.166667h;

Pyridine-3-sulfonyl chloride; In tetrahydrofuran; at 0 ℃; for 0.25h;

Reference yield:

: 1055306-62-1
tert-butyl [bromo(difluoro)acetyl]prop-2-en-1-ylcarbamate

: 1055306-76-7
1-(2,4-dimethoxyphenyl)-N-{[4-fluoro-5-(2-fluoropyridin-3-yl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]methyl}-N-methylmethanamine

Guidance literature:: Multi-step reaction with 6 steps

1.1: copper(I) bromide; [2,2]bipyridinyl / 1,2-dichloro-ethane / 24 h / 80 °C / Inert atmosphere

2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 1 h / 0 - 20 °C

3.1: lithium diisopropyl amide; n-butyllithium / tetrahydrofuran; hexane / 2 h / -78 °C / Inert atmosphere

3.2: 3 h / -78 °C / Inert atmosphere

4.1: acetic acid; hydrogenchloride / 1 h / 20 °C

5.1: sodium hydride / tetrahydrofuran; hexane / 18 h / 0 - 60 °C

5.2: 1 h / 0 °C

6.1: sodium hydride / tetrahydrofuran / 0.17 h / 0 °C

6.2: 0.17 h

6.3: 0.25 h

With hydrogenchloride; [2,2]bipyridinyl; n-butyllithium; sodium hydride; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; copper(I) bromide; lithium diisopropyl amide; In tetrahydrofuran; hexane; 1,2-dichloro-ethane;
DOI:10.1016/j.bmc.2017.04.034

Reference yield:

: 1055306-63-2
tert-butyl (4RS)-4-(bromomethyl)-3,3-difluoro-2-oxopyrrolidine-1-carboxylate

: 1055306-76-7
1-(2,4-dimethoxyphenyl)-N-{[4-fluoro-5-(2-fluoropyridin-3-yl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]methyl}-N-methylmethanamine

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 1 h / 0 - 20 °C

2.1: lithium diisopropyl amide; n-butyllithium / tetrahydrofuran; hexane / 2 h / -78 °C / Inert atmosphere

2.2: 3 h / -78 °C / Inert atmosphere

3.1: acetic acid; hydrogenchloride / 1 h / 20 °C

4.1: sodium hydride / tetrahydrofuran; hexane / 18 h / 0 - 60 °C

4.2: 1 h / 0 °C

5.1: sodium hydride / tetrahydrofuran / 0.17 h / 0 °C

5.2: 0.17 h

5.3: 0.25 h

With hydrogenchloride; n-butyllithium; sodium hydride; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium diisopropyl amide; In tetrahydrofuran; hexane;
DOI:10.1016/j.bmc.2017.04.034