benzhydryl (6R,7R, Z)-3-(acetoxymethyl)-7-(2-(methoxyimino)-2-(2-(2-(tritylamino)acetamido)thiazol-4-yl)acetamido)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate

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Chemical Name:benzhydryl (6R,7R, Z)-3-(acetoxymethyl)-7-(2-(methoxyimino)-2-(2-(2-(tritylamino)acetamido)thiazol-4-yl)acetamido)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate
CAS No.:1374584-89-0
Molecular Formula:C₅₀H₄₄N₆O₈S₂
Molecular Weight:921.067
Hs Code.:

benzhydryl (6R,7R, Z)-3-(acetoxymethyl)-7-(2-(methoxyimino)-2-(2-(2-(tritylamino)acetamido)thiazol-4-yl)acetamido)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate

Synonyms:benzhydryl (6R,7R, Z)-3-(acetoxymethyl)-7-(2-(methoxyimino)-2-(2-(2-(tritylamino)acetamido)thiazol-4-yl)acetamido)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate

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Chemical Property of benzhydryl (6R,7R, Z)-3-(acetoxymethyl)-7-(2-(methoxyimino)-2-(2-(2-(tritylamino)acetamido)thiazol-4-yl)acetamido)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate

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Technology Process of benzhydryl (6R,7R, Z)-3-(acetoxymethyl)-7-(2-(methoxyimino)-2-(2-(2-(tritylamino)acetamido)thiazol-4-yl)acetamido)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate

There total 2 articles about benzhydryl (6R,7R, Z)-3-(acetoxymethyl)-7-(2-(methoxyimino)-2-(2-(2-(tritylamino)acetamido)thiazol-4-yl)acetamido)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: benzhydryl (6R,7R,Z)-3-(acetoxymethyl)-7-(2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetamido)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate

: 5893-05-0
Trt-Gly

: 1374584-89-0
benzhydryl (6R,7R, Z)-3-(acetoxymethyl)-7-(2-(methoxyimino)-2-(2-(2-(tritylamino)acetamido)thiazol-4-yl)acetamido)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate

Guidance literature:: With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 0 - 20 ℃; for 8h; Inert atmosphere;
DOI:10.1002/anie.201107810

Reference yield:

: 63527-52-6,152186-43-1
cefotaxime

: 908093-98-1
diazodiphenylmethane

: 1374584-89-0
benzhydryl (6R,7R, Z)-3-(acetoxymethyl)-7-(2-(methoxyimino)-2-(2-(2-(tritylamino)acetamido)thiazol-4-yl)acetamido)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / water; acetonitrile / 0.75 h / 20 °C / pH 3 / Inert atmosphere

2: benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / acetonitrile / 8 h / 0 - 20 °C / Inert atmosphere

With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; In water; acetonitrile;
DOI:10.1002/anie.201107810