4-methylamino-3-nitro-benzoic acid-N-phenyl-N-(2-ethoxycarbonylethyl)amide

Base Information

• Chemical Name: 4-methylamino-3-nitro-benzoic acid-N-phenyl-N-(2-ethoxycarbonylethyl)amide
• CAS No.: 211915-71-8
• Molecular Formula: C₁₉H₂₁N₃O₅
• Molecular Weight: 371.393
• Mol file: 211915-71-8.mol

Synonyms:4-methylamino-3-nitro-benzoic acid-N-phenyl-N-(2-ethoxycarbonylethyl)amide

Chemical Property of 4-methylamino-3-nitro-benzoic acid-N-phenyl-N-(2-ethoxycarbonylethyl)amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-methylamino-3-nitro-benzoic acid-N-phenyl-N-(2-ethoxycarbonylethyl)amide

There total 4 articles about 4-methylamino-3-nitro-benzoic acid-N-phenyl-N-(2-ethoxycarbonylethyl)amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

ethyl 3-phenylaminopropionate (62750-11-2) + 4-methylamino-3-nitro-benzoic acid chloride (82357-48-0) → 4-methylamino-3-nitro-benzoic acid-N-phenyl-N-(2-ethoxycarbonylethyl)amide (211915-71-8)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 12h; Reagent/catalyst; Solvent;

Reference yield:

4-(methylamino)-3-nitrobenzoic acid (41263-74-5) → 4-methylamino-3-nitro-benzoic acid-N-phenyl-N-(2-ethoxycarbonylethyl)amide (211915-71-8)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂ / dimethylformamide / 0.5 h / Heating

2: Et₃N / tetrahydrofuran / 20 °C

With thionyl chloride; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/jm0109513

Reference yield:

aniline (62-53-3) → 4-methylamino-3-nitro-benzoic acid-N-phenyl-N-(2-ethoxycarbonylethyl)amide (211915-71-8)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / ethanol / 24 h / 100 °C / Inert atmosphere

2: triethylamine / dichloromethane / 12 h / 20 °C

With triethylamine; In ethanol; dichloromethane;

upstream raw materials:

ethyl 3-phenylaminopropionate

4-methylamino-3-nitro-benzoic acid chloride

4-(methylamino)-3-nitrobenzoic acid

aniline

Downstream raw materials:

3-({2-[(4-carbamimidoyl-phenylamino)-methyl]-1-methyl-1H-benzoimidazole-5-carbonyl}-phenyl-amino)-propionic acid ethyl ester

1-methyl-2-[N-(4-cyanophenyl)-aminomethyl]-benzimidazol-5-yl-carboxylic acid-N-phenyl-N-(2-ethoxycarbonylethyl)-amide

3-Amino-4-methylamino-benzoic acid-N-phenyl-N-(2-ethoxy-carbonylethyl)-amide