Technology Process of N-(2-benzyloxyphenyl)cycloheptylcarboxamide
There total 1 articles about N-(2-benzyloxyphenyl)cycloheptylcarboxamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
dichloromethane;
Ambient temperature;
DOI:10.1248/cpb.47.755
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 60 percent / BH3*THF / tetrahydrofuran / 72 h / Ambient temperature
2: pyridine / CH2Cl2 / 1 h / Ambient temperature
3: NH2NH2*H2O / ethanol; CHCl3 / Ambient temperature
4: 1.) THF, RT, 10 min, 2.) toluene, reflux, 1 h
5: 99 percent / H2 / 5 percent Pd/C / methanol / 3 h / 760 Torr
6: 60 percent / K2CO3 / dimethylformamide / 3.5 h / 70 °C
7: 94 percent / 0.1 N aq. NaOH / tetrahydrofuran / 5 h / Ambient temperature
With
pyridine; sodium hydroxide; borane-THF; hydrogen; potassium carbonate; hydrazine hydrate;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; chloroform; N,N-dimethyl-formamide;
DOI:10.1248/cpb.47.755
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 60 percent / BH3*THF / tetrahydrofuran / 72 h / Ambient temperature
2: pyridine / CH2Cl2 / 1 h / Ambient temperature
3: NH2NH2*H2O / ethanol; CHCl3 / Ambient temperature
4: 1.) pyridine / 1.) CH2Cl2, -30 deg C, 0.5 h, 2.) CH2Cl2, RT, overnight
5: 100 percent / H2 / 5 percent Pd/C / methanol / 3 h / 760 Torr
With
pyridine; borane-THF; hydrogen; hydrazine hydrate;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; chloroform;
DOI:10.1248/cpb.47.755
