2-(Methoxymethoxy)-1-[2-(methoxymethoxy)naphthalen-1-yl]naphthalene

Base Information

• Chemical Name: 2-(Methoxymethoxy)-1-[2-(methoxymethoxy)naphthalen-1-yl]naphthalene
• CAS No.: 173831-50-0
• Molecular Formula: C24H22O4
• Molecular Weight: 374.436
• Hs Code.: 29093090
• European Community (EC) Number: 633-997-1,634-273-8,804-314-6
• Nikkaji Number: J1.188.401F,J3.322.872D
• Mol file: 173831-50-0.mol

Synonyms:173831-50-0;142128-92-5;(R)-2,2'-Bis(methoxymethoxy)-1,1'-binaphthalene;(S)-2,2'-Bis(methoxymethoxy)-1,1'-binaphthalene;74292-20-9;(R)-2,2'-Bis(methoxymethoxy)-1,1'-binaphthyl;2,2'-BIS(METHOXYMETHOXY)-1,1'-BINAPHTHALENE;2-(methoxymethoxy)-1-[2-(methoxymethoxy)naphthalen-1-yl]naphthalene;(R)-(+)-2,2'-Bis(methoxymethoxy)-1,1'-binaphthyl;1,1'-Binaphthalene, 2,2'-bis(methoxymethoxy)-;(S)-(-)-2,2'-BIS(METHOXYMETHOXY)-1,1'-BINAPHTHYL;1,1'-Binaphthalene, 2,2'-bis(methoxymethoxy)-, (1R)-;(S)-2,2'-BIS(METHOXYMETHOXY)-1,1'-BINAPHTHYL;(R)-(+)-2,2'-BIS(METHOXYMETHOXY)-1,1'-BINAPHTHALENE;(R)-(+)-2,2/'-BIS(METHOXYMETHOXY)-1,1/'-BINAPHTHYL;(R)-2,2/'-Bis(methoxymethoxy)-1,1/'-binaphthalene;SCHEMBL1446528;AC9224;AKOS015911249;CS-W011783;SC11849;1,1'-Bi[2-(methoxymethoxy)naphthalene];DS-14105;SY009989;SY009990;B3202;B3203;CS-0031335;FT-0663336;C73331;10.14272/YIAQRNNJNMLGTP-UHFFFAOYSA-N.1;A885237;(aR)-2,2'-Bis(methoxymethoxy)-1,1'-binaphthalene;doi:10.14272/YIAQRNNJNMLGTP-UHFFFAOYSA-N.1;J-010946;2,2'-Bis(methoxymethoxy)-1,1'-binaphthalene, 97%;(R)-(+)-2,2'-Bis(methoxymethoxy)-1,1'-binaphthalene, 97%;(S)-(-)-2,2'-Bis(methoxymethoxy)-1,1'-binaphthalene, 97%;(S)-(-)-2,2?-BIS(METHOXYMETHOXY)-1,1?-BINAPHTHALENE;(R)-(+)-2,2 inverted exclamation mark -Bis(methoxymethoxy)-1,1 inverted exclamation mark -binaphthalene;(S)-(-)-2,2 inverted exclamation mark -Bis(methoxymethoxy)-1,1 inverted exclamation mark -binaphthalene

Chemical Property of 2-(Methoxymethoxy)-1-[2-(methoxymethoxy)naphthalen-1-yl]naphthalene

Chemical Property:

• Melting Point: 92-96 °C(lit.)
• Boiling Point: 477.809 °C at 760 mmHg
• Flash Point: 126.215 °C
• PSA: 36.92000
• Density: 1.182 g/cm³
• LogP: 5.62540
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility.: soluble in Toluene
• XLogP3: 5.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 7
• Exact Mass: 374.15180918
• Heavy Atom Count: 28
• Complexity: 428

Purity/Quality:

98%,99%, ^*data from raw suppliers

(R)-2,2’-Bis(methoxymethoxy)-1,1''-binaphthyl ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi, N
• Hazard Codes: Xi,N
• Statements: 41-50/53
• Safety Statements: 26-39-60-61-36/39-25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COCOC1=C(C2=CC=CC=C2C=C1)C3=C(C=CC4=CC=CC=C43)OCOC
• Uses: An intermediate in the symmetric synthesis of BINOL-terpyridine ligands. 3- or 3,3′-di-substituted products can be obtained easily via ortho-metallation and subsequent treatment with an electrophile to give the corresponding BINOL derivatives.

Technology Process of 2-(Methoxymethoxy)-1-[2-(methoxymethoxy)naphthalen-1-yl]naphthalene

There total 5 articles about 2-(Methoxymethoxy)-1-[2-(methoxymethoxy)naphthalen-1-yl]naphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

chloromethyl methyl ether (107-30-2) + 1,1'-bi-2-naphthol (602-09-5) → rac-2,2'-bis-(methoxymethoxy)-1,1'-binaphthalene (173831-50-0)

Guidance literature:

1,1'-bi-2-naphthol; With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃;

chloromethyl methyl ether; In tetrahydrofuran; at 20 ℃; for 4.5h;

DOI:10.1021/ol0490882

Reference yield: 98.0%

(R)-binaphthol (602-09-5,18531-99-2,18531-94-7) + chloromethyl methyl ether (107-30-2) → (R,R)-2,2'-bis(methoxymethoxy)-1,1'-binaphthol (142128-92-5,173831-50-0,74292-20-9)

Guidance literature:

(R)-binaphthol; With sodium hydride; In tetrahydrofuran; at 0 - 10 ℃; for 1h;

chloromethyl methyl ether; In tetrahydrofuran; at 0 - 10 ℃;

Reference yield: 95.0%

(S)-[1,1']-binaphthalenyl-2,2'-diol (18531-99-2) + chloromethyl methyl ether (107-30-2) → rac-2,2'-bis-(methoxymethoxy)-1,1'-binaphthalene (173831-50-0)

Guidance literature:

(S)-[1,1']-binaphthalenyl-2,2'-diol; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; for 0.25h; Inert atmosphere;

chloromethyl methyl ether; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; for 1h; Inert atmosphere;

DOI:10.1021/jo402277p

upstream raw materials:

chloromethyl methyl ether

1,1'-bi-2-naphthol

β-naphthol

methoxymethoxy chloride

Downstream raw materials:

2,2'-Bis-methoxymethoxy-3,3'-bis-triphenylsilanyl-[1,1']binaphthalenyl

(±)?3,3'?dibromo?2,2'?bis(methoxymethyl)?1,1'?binaphthalene

(R)-3,3'-dimethyl-1,1'-binaphthalene-2,2'-diol

1,1'-bi-2-naphthol