2,2'-(2S,2'S)-[(2,3,6,7-tetrahydro-1,2,7-thiadiazepine-1,1-dioxido-2,7-diyl)]-3,3'-diphenyl bis-propionic acid dimethyl ester

Base Information

Chemical Name:2,2'-(2S,2'S)-[(2,3,6,7-tetrahydro-1,2,7-thiadiazepine-1,1-dioxido-2,7-diyl)]-3,3'-diphenyl bis-propionic acid dimethyl ester
CAS No.:323178-17-2
Molecular Formula:C₂₄H₂₈N₂O₆S
Molecular Weight:472.562
Hs Code.:

Synonyms:2,2'-(2S,2'S)-[(2,3,6,7-tetrahydro-1,2,7-thiadiazepine-1,1-dioxido-2,7-diyl)]-3,3'-diphenyl bis-propionic acid dimethyl ester

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Chemical Property of 2,2'-(2S,2'S)-[(2,3,6,7-tetrahydro-1,2,7-thiadiazepine-1,1-dioxido-2,7-diyl)]-3,3'-diphenyl bis-propionic acid dimethyl ester

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Technology Process of 2,2'-(2S,2'S)-[(2,3,6,7-tetrahydro-1,2,7-thiadiazepine-1,1-dioxido-2,7-diyl)]-3,3'-diphenyl bis-propionic acid dimethyl ester

There total 2 articles about 2,2'-(2S,2'S)-[(2,3,6,7-tetrahydro-1,2,7-thiadiazepine-1,1-dioxido-2,7-diyl)]-3,3'-diphenyl bis-propionic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 323178-12-7
N,N'-bis(2-propenyl)-N,N'-sulfonyl bis-L-phenylalanine dimethyl ester

: 323178-17-2
2,2'-(2S,2'S)-[(2,3,6,7-tetrahydro-1,2,7-thiadiazepine-1,1-dioxido-2,7-diyl)]-3,3'-diphenyl bis-propionic acid dimethyl ester

Guidance literature:: With Grubbs catalyst first generation; In dichloromethane; for 1.5h; Heating;
DOI:10.1016/S0040-4020(00)00885-1

Reference yield:

: 249538-97-4
N,N'-bis[(2S,2'S)-2-(methoxycarbonyl)phenethyl]sulfamide

: 323178-17-2
2,2'-(2S,2'S)-[(2,3,6,7-tetrahydro-1,2,7-thiadiazepine-1,1-dioxido-2,7-diyl)]-3,3'-diphenyl bis-propionic acid dimethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / K₂CO₃ / acetonitrile / 14 h / 70 °C

2: 96 percent / RuCl₂(Cy₃P)2CHPh / CH₂Cl₂ / 1.5 h / Heating

With Grubbs catalyst first generation; potassium carbonate; In dichloromethane; acetonitrile; 1: Alkylation / 2: ring-closing metathesis;
DOI:10.1016/S0040-4020(00)00885-1