249538-97-4

Upstream product

• 63-91-2 L-phenylalanine 
• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 
• 2577-90-4 methyl (2S)-2-amino-3-phenylpropanoate 

Downstream Products

• 323178-12-7 N,N'-bis(2-propenyl)-N,N'-sulfonyl bis-L-phenylalanine dimethyl ester 
• 915697-11-9 N,N'-bis[(S)-1-benzyl-2-hydroxyethyl] sulfamide 
• 323178-17-2 2,2'-(2S,2'S)-[(2,3,6,7-tetrahydro-1,2,7-thiadiazepine-1,1-dioxido-2,7-diyl)]-3,3'-diphenyl bis-propionic acid dimethyl ester 
• 915697-14-2 N,N'-bis[(S)-1-benzyl-2-chloroethyl] sulfamide 

Relevant academic research and scientific papers

Cyclosulfamides as constraint dipeptides: The synthesis and structure of chiral substituted 1,2,5-thiadiazolidine 1,1-dioxides: Evaluation of the toxicity

A general synthesis for the preparation of chiral N-N′ substituted 1,2,5-thiadiazolidine 1,1-dioxides has been developed beginning with proteogenic amino acid, sulfuryl chloride, and dibromoethane. The selected chemistry and spectral properties of these c

Synthesis, experimental characterization and theoretical calculation of novel charge transfer complex between (S, S)-bis-N,N-sulfonyl bis –L-phenylalanine dimethylester and 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ)

Charge transfer complex (CTC) formed between (S, S)-bis-N, N-sulfonyl bis-L-phenylalanine dimethylester as donor and 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ) as acceptor, has been studied spectrophotometrically. Benesi-Hildebrand and molar ratio meth

Synthesis of new pseudonucleosides containing sulfamylated derivatives of natural amino acids as aglycone

New chiral sulfahydantoins have been synthesized via alkaline cyclisation, starting from symmetric sulfamide derivatives of natural amino acids. Tetraacetyl ribofuranose was used in the glycosylation step in order to obtain the pseudonucleosides in β-anom

Investigation on the Anticancer Activity of Symmetric and Unsymmetric Cyclic Sulfamides

The sulfamide functional group has been extensively employed in organic synthesis to discover probes and drugs in various applications such as cancer, human immunodeficiency virus (HIV), virus, and diabetes. Herein, we describe the synthesis of 7-membered

Ultrasonic assisted green protocol for the synthesis of sulfamides

An improved environmentally benign method for synthesis of sulfamides under focused ultrasound irradiation and under solvent-free and catalyst-free conditions has been carried out by the reaction of amines or amino esters with sulfuryl chloride. This approach allows the synthesis of products in excellent yields and in short reaction time.

Sulfahydantoins as tripeptide constraints: Synthesis and structure of chiral substituted 3-oxo-1,2,5-thiadiazolidine 1,1-dioxides

A sulfahydantoin (3-oxo-1,2,5-thiadiazohdine 1,1-dioxides) motif is used as a new type of peptidic constraint to lock two consecutive amide nitrogens by a sulfonyl bridge. The 5membered heterocyclic motif was prepared starting from proteogenic and synthetic amino acids and chlorosulfonyl isocyanate. Constrained dipeptides were obtained under alkaline conditions (methoxide or tert-butoxide) by cyclization of symmetric and dissymmetric sulfamides. The absolute configuration of the chiral centers for the derivative L-Phe-D-Ala, a congener of the series, was established by X-ray diffraction crystallographic analysis. In addition, the chemo-, regio-, and stereoselectivities of the reactions were studied. In the acylated derivatives, the sulfahydantoin constraint induces a unique backbone conformation with coplanarity of two consecutive peptide bonds.