(S)-1-[3-(TRIFLUOROMETHYL)PHENYL]ETHANOL

Base Information

• Chemical Name: (S)-1-[3-(TRIFLUOROMETHYL)PHENYL]ETHANOL
• CAS No.: 96789-80-9
• Molecular Formula: C₉H₉F₃O
• Molecular Weight: 190.165
• Hs Code.: 2906290090
• Mol file: 96789-80-9.mol

Synonyms:Benzenemethanol,a-methyl-3-(trifluoromethyl)-,(S)-; (S)-(-)-1-(m-Trifluoromethylphenyl)ethanol; (S)-1-(3-Trifluoromethylphenyl)ethanol

Chemical Property of (S)-1-[3-(TRIFLUOROMETHYL)PHENYL]ETHANOL

Chemical Property:

• Vapor Pressure: 0.14mmHg at 25°C
• Boiling Point: 206.9°Cat760mmHg
• Flash Point: 96.1°C
• PSA: 20.23000
• Density: 1.234g/cm³
• LogP: 2.75870
• Storage Temp.: 2-8°C

Purity/Quality:

98%Min ^*data from raw suppliers

(S)-1-[3-(Trifluoromethyl)phenyl]ethanol ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (S)-1-[3-(TRIFLUOROMETHYL)PHENYL]ETHANOL is a useful research chemical.

Technology Process of (S)-1-[3-(TRIFLUOROMETHYL)PHENYL]ETHANOL

There total 53 articles about (S)-1-[3-(TRIFLUOROMETHYL)PHENYL]ETHANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.7%

3'-(trifluoromethyl)acetophenone (349-76-8) → (R)-1-(3-trifluoromethylphenyl)ethanol (454-91-1,68120-40-1,96789-80-9,127852-24-8)

Guidance literature:

With potassium tert-butylate; hydrogen; RuCl₂[(S)-XylHexaPHEMP][(S)-1,1-dianisyl-2-iPr-1,2-Et(NH₂)2]; In isopropyl alcohol; tert-butyl alcohol; at 20 ℃; for 0.683333h; under 6205.94 Torr;

DOI:10.1002/adsc.200390025

Reference yield: 99.0%

3'-(trifluoromethyl)acetophenone (349-76-8) → (R)-1-(3-trifluoromethylphenyl)ethanol (454-91-1,68120-40-1,96789-80-9,127852-24-8) + triethylamine (121-44-8)

Guidance literature:

Reference yield: 99.0%

3'-(trifluoromethyl)acetophenone (349-76-8) → (S)-1-(3-trifluoromethylphenyl)ethanol (454-91-1,68120-40-1,127852-24-8,96789-80-9)

Guidance literature:

With D-glucose; In aq. phosphate buffer; at 25 ℃; for 24h; pH=7.0; stereoselective reaction;

DOI:10.3390/md16020062

upstream raw materials:

3'-(trifluoromethyl)acetophenone

C₁₅H₂₃F₃O₃Si

1-(3-trifluoromethylphenyl)ethanol

3-(trifluoromethyl)styrene

Downstream raw materials:

(R)-1-chloro-1-(3-trifluoromethylphenyl)ethane

C₁₆H₁₂BrF₃O₂

C₁₆H₁₂BrF₃O₂

(1R)-1-[3-(trifluoromethyl)phenyl]ethan-1-amine hydrochloride

Refernces

• 1、 Tran, Hai N.,Stanley, Levi M.. "Nickel-Catalyzed Enantioselective Hydroboration of Vinylarenes". supporting information. p. 395 - 399. Retrieved 2021/12/27.
• 2、 Huo, Shangfei,Chen, Hong,Zuo, Weiwei. "A Cobalt(II) Complex Bearing the Amine(imine)diphosphine PN(H)NP Ligand for Asymmetric Transfer Hydrogenation of Ketones". supporting information. p. 37 - 42. Retrieved 2020/10/21.