(S)-5,5,5-Trifluoro-2-((R)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionylamino)-pentanoic acid methyl ester

Base Information

Chemical Name:(S)-5,5,5-Trifluoro-2-((R)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionylamino)-pentanoic acid methyl ester
CAS No.:122490-05-5
Molecular Formula:C₁₆H₁₇F₆NO₄
Molecular Weight:401.306
Hs Code.:

Synonyms:(S)-5,5,5-Trifluoro-2-((R)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionylamino)-pentanoic acid methyl ester

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Chemical Property of (S)-5,5,5-Trifluoro-2-((R)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionylamino)-pentanoic acid methyl ester

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Technology Process of (S)-5,5,5-Trifluoro-2-((R)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionylamino)-pentanoic acid methyl ester

There total 3 articles about (S)-5,5,5-Trifluoro-2-((R)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionylamino)-pentanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 20445-31-2
R-(+)-α-trifluoromethyl-α-methoxy-phenylacetic acid

: 122490-04-4
(S)-5,5,5-trifluoronorvaline methyl ester hydrochloride

: 122490-05-5
(S)-5,5,5-Trifluoro-2-((R)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionylamino)-pentanoic acid methyl ester

Guidance literature:: With 4-methyl-morpholine; dicyclohexyl-carbodiimide; In tetrahydrofuran; 1.) 0 deg C, 3 h, 2.) RT, 24 h;
DOI:10.1021/jo00280a014

Reference yield:

: 122565-28-0,23809-57-6
(S)-2-amino-5,5,5-trifluoropentanoic acid

: 122490-05-5
(S)-5,5,5-Trifluoro-2-((R)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionylamino)-pentanoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / SOCl₂ / 1.) -10 deg C, 15 min, 2.) RT, 24 h

2: 87 percent / N-methylmorpholine, N,N'-dicyclohexylcarbodiimide / tetrahydrofuran / 1.) 0 deg C, 3 h, 2.) RT, 24 h

With 4-methyl-morpholine; thionyl chloride; dicyclohexyl-carbodiimide; In tetrahydrofuran;
DOI:10.1021/jo00280a014

Reference yield:

: 96563-56-3
N-acetyl-5,5,5-trifluoronorvaline

: 122490-05-5
(S)-5,5,5-Trifluoro-2-((R)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionylamino)-pentanoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 40 percent / porcine kidney acylase I / H₂O / 14 h / 25 °C / pH 7

2: 92 percent / SOCl₂ / 1.) -10 deg C, 15 min, 2.) RT, 24 h

3: 87 percent / N-methylmorpholine, N,N'-dicyclohexylcarbodiimide / tetrahydrofuran / 1.) 0 deg C, 3 h, 2.) RT, 24 h

With 4-methyl-morpholine; thionyl chloride; porcine kidney acylase I; dicyclohexyl-carbodiimide; In tetrahydrofuran; water;
DOI:10.1021/jo00280a014