(S)-2-((2S,3S,2'R,3'R)-3-Phenoxy-2,2'-diphenyl-[1,3']biazetidinyl-1'-yl)-propan-1-ol

Base Information

• Chemical Name: (S)-2-((2S,3S,2'R,3'R)-3-Phenoxy-2,2'-diphenyl-[1,3']biazetidinyl-1'-yl)-propan-1-ol
• CAS No.: 98380-62-2
• Molecular Formula: C₂₇H₃₀N₂O₂
• Molecular Weight: 414.547

Synonyms:(S)-2-((2S,3S,2'R,3'R)-3-Phenoxy-2,2'-diphenyl-[1,3']biazetidinyl-1'-yl)-propan-1-ol

Chemical Property of (S)-2-((2S,3S,2'R,3'R)-3-Phenoxy-2,2'-diphenyl-[1,3']biazetidinyl-1'-yl)-propan-1-ol

Chemical Property:

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Technology Process of (S)-2-((2S,3S,2'R,3'R)-3-Phenoxy-2,2'-diphenyl-[1,3']biazetidinyl-1'-yl)-propan-1-ol

There total 6 articles about (S)-2-((2S,3S,2'R,3'R)-3-Phenoxy-2,2'-diphenyl-[1,3']biazetidinyl-1'-yl)-propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

1-<(S)-1-(tert-butoxycarbonyl)ethyl>-(3R,4S)-3-<(3'S,4'R)-2'-oxo-3'-phenoxy-4'-phenylazetidin-1'-yl>-4-phenylazetidin-2-one (136778-91-1) → (2S,3S)-1-<(S)-1-methyl-2-hydroxyethyl>-2-phenyl-3-<(2'R,3'R)-2'-phenyl-3'-phenoxyazetidinyl>azetidine (98380-62-2,136778-99-9,136779-00-5)

Guidance literature:

With chlorohydroalane; In diethyl ether; Heating;

DOI:10.1021/jo00018a012

Reference yield: 66.0%

1-<(S)-1-(tert-butoxycarbonyl)ethyl>-(3S,4R)-3-<(3'R,4'S)-2'-oxo-3'-phenoxy-4'-phenylazrtidin-1'-yl>-4-phenylazetidin-2-one (98380-57-5) → (S)-2-((2S,3S,2'R,3'R)-3-Phenoxy-2,2'-diphenyl-[1,3']biazetidinyl-1'-yl)-propan-1-ol (98380-62-2)

Guidance literature:

With chlorohydroalane; In diethyl ether; for 2h; Heating;

DOI:10.1016/S0040-4039(00)94772-5

Reference yield:

(S)-2-((3R,4S)-2-Oxo-4-phenyl-3-{[1-phenyl-meth-(E)-ylidene]-amino}-azetidin-1-yl)-propionic acid tert-butyl ester (78688-68-3,78738-82-6) → (2S,3S)-1-<(S)-1-methyl-2-hydroxyethyl>-2-phenyl-3-<(2'R,3'R)-2'-phenyl-3'-phenoxyazetidinyl>azetidine (98380-62-2,136778-99-9,136779-00-5)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / CH₂Cl₂ / 0 deg C -> RT, overnight

2: 77 percent / AlH₂Cl / diethyl ether / Heating

With chlorohydroalane; triethylamine; In diethyl ether; dichloromethane;

DOI:10.1021/jo00018a012

upstream raw materials:

1-<(S)-1-(tert-butoxycarbonyl)ethyl>-(3S,4R)-3-<(3'R,4'S)-2'-oxo-3'-phenoxy-4'-phenylazrtidin-1'-yl>-4-phenylazetidin-2-one

(S)-2-((3S,4R)-2-Oxo-4-phenyl-3-{[1-phenyl-meth-(E)-ylidene]-amino}-azetidin-1-yl)-propionic acid tert-butyl ester

Phenoxyacetyl chloride

1-<(S)-1-(tert-butoxycarbonyl)ethyl>-(3R,4S)-3-<(3'S,4'R)-2'-oxo-3'-phenoxy-4'-phenylazetidin-1'-yl>-4-phenylazetidin-2-one

Downstream raw materials:

(2S,5R,8S)-1-phenyl-2,5-dibenzyl-8-methyl-1,9-dioxa-4,7-diazadecane

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