1-benzyl-4-(pyrid-3-yl)-4-((4-carboethoxymethylpiperazin-1-yl)carboxamido)piperidine

Base Information

Chemical Name:1-benzyl-4-(pyrid-3-yl)-4-((4-carboethoxymethylpiperazin-1-yl)carboxamido)piperidine
CAS No.:209667-50-5
Molecular Formula:C₂₆H₃₄N₄O₃
Molecular Weight:450.581
Hs Code.:

Synonyms:1-benzyl-4-(pyrid-3-yl)-4-((4-carboethoxymethylpiperazin-1-yl)carboxamido)piperidine

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Chemical Property of 1-benzyl-4-(pyrid-3-yl)-4-((4-carboethoxymethylpiperazin-1-yl)carboxamido)piperidine

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Technology Process of 1-benzyl-4-(pyrid-3-yl)-4-((4-carboethoxymethylpiperazin-1-yl)carboxamido)piperidine

There total 5 articles about 1-benzyl-4-(pyrid-3-yl)-4-((4-carboethoxymethylpiperazin-1-yl)carboxamido)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 40004-08-8
1-(Ethoxycarbonylmethyl)piperazine

: 199439-91-3
1-benzyl-4-(pyrid-3-yl)-piperidine-4-carboxylic acid

: 209667-50-5
1-benzyl-4-(pyrid-3-yl)-4-((4-carboethoxymethylpiperazin-1-yl)carboxamido)piperidine

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In DMF (N,N-dimethyl-formamide); for 60h;

Reference yield:

: 1-benzyl-4-(pyrid-3-yl)-4-cyanopiperidine hydrochloric acid salt

: 209667-50-5
1-benzyl-4-(pyrid-3-yl)-4-((4-carboethoxymethylpiperazin-1-yl)carboxamido)piperidine

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide; water / ethylene glycol / 15 h / Heating / reflux

2: methanol / 50 °C

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / DMF (N,N-dimethyl-formamide) / 60 h

With sodium hydroxide; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; DMF (N,N-dimethyl-formamide); ethylene glycol;

Reference yield:

: 6443-85-2
3-pyridinylacetonitrile

: 209667-50-5
1-benzyl-4-(pyrid-3-yl)-4-((4-carboethoxymethylpiperazin-1-yl)carboxamido)piperidine

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydroxide; cetyltributylphosphonium bromide / water / 1.5 h

2: sodium hydroxide; water / ethylene glycol / 15 h / Heating / reflux

3: methanol / 50 °C

4: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / DMF (N,N-dimethyl-formamide) / 60 h

With sodium hydroxide; water; cetyltributylphosphonium bromide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; DMF (N,N-dimethyl-formamide); water; ethylene glycol;