methyl (R)-2-[1-(biphenyl-4-ylmethyl)-4-(cyclohexylmethyl)-3,6-dioxopiperazin-2-yl]acetate

Base Information

Chemical Name:methyl (R)-2-[1-(biphenyl-4-ylmethyl)-4-(cyclohexylmethyl)-3,6-dioxopiperazin-2-yl]acetate
CAS No.:1528534-36-2
Molecular Formula:C₂₇H₃₂N₂O₄
Molecular Weight:448.562
Hs Code.:

Synonyms:methyl (R)-2-[1-(biphenyl-4-ylmethyl)-4-(cyclohexylmethyl)-3,6-dioxopiperazin-2-yl]acetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl (R)-2-[1-(biphenyl-4-ylmethyl)-4-(cyclohexylmethyl)-3,6-dioxopiperazin-2-yl]acetate

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Technology Process of methyl (R)-2-[1-(biphenyl-4-ylmethyl)-4-(cyclohexylmethyl)-3,6-dioxopiperazin-2-yl]acetate

There total 5 articles about methyl (R)-2-[1-(biphenyl-4-ylmethyl)-4-(cyclohexylmethyl)-3,6-dioxopiperazin-2-yl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1528534-31-7
dimethyl (R)-2-[N-(biphenyl-4-ylmethyl)-N-(2-chloroacetyl)amino]butanedioate

: 3218-02-8
cyclohexylmethylamine

: 1528534-36-2
methyl (R)-2-[1-(biphenyl-4-ylmethyl)-4-(cyclohexylmethyl)-3,6-dioxopiperazin-2-yl]acetate

Guidance literature:: With triethylamine; In acetonitrile; at 20 ℃; for 16h; Molecular sieve;
DOI:10.1016/j.bmc.2013.11.033

Reference yield: 74.0%

: dimethyl (R)-2-[N-(biphenyl-4-ylmethyl)-N-(2-chloroacetyl)amino]butanedioate

: 3218-02-8
cyclohexylmethylamine

: 1528534-36-2
methyl (R)-2-[1-(biphenyl-4-ylmethyl)-4-(cyclohexylmethyl)-3,6-dioxopiperazin-2-yl]acetate

Guidance literature:: With triethylamine; In acetonitrile; at 20 ℃; for 16h; Molecular sieve;
DOI:10.1021/jm401707t

Reference yield:

: C₁₉H₂₁NO₄

: 1528534-36-2
methyl (R)-2-[1-(biphenyl-4-ylmethyl)-4-(cyclohexylmethyl)-3,6-dioxopiperazin-2-yl]acetate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 2.5 h / 20 °C / Inert atmosphere; Cooling with ice

2: triethylamine / acetonitrile / 16 h / 20 °C / Molecular sieve

With triethylamine; In dichloromethane; acetonitrile;
DOI:10.1021/jm401707t