(R)-2-[1-(Biphenyl-4-ylmethyl)-4-(cyclohexylmethyl)piperazin-2-yl]ethanol

Base Information

• Chemical Name: (R)-2-[1-(Biphenyl-4-ylmethyl)-4-(cyclohexylmethyl)piperazin-2-yl]ethanol
• CAS No.: 1528534-19-1
• Molecular Formula: C₂₆H₃₆N₂O
• Molecular Weight: 392.585
• Mol file: 1528534-19-1.mol

Synonyms:(R)-2-[1-(Biphenyl-4-ylmethyl)-4-(cyclohexylmethyl)piperazin-2-yl]ethanol

Chemical Property of (R)-2-[1-(Biphenyl-4-ylmethyl)-4-(cyclohexylmethyl)piperazin-2-yl]ethanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-2-[1-(Biphenyl-4-ylmethyl)-4-(cyclohexylmethyl)piperazin-2-yl]ethanol

There total 2 articles about (R)-2-[1-(Biphenyl-4-ylmethyl)-4-(cyclohexylmethyl)piperazin-2-yl]ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

methyl (R)-2-[1-(biphenyl-4-ylmethyl)-4-(cyclohexylmethyl)-3,6-dioxopiperazin-2-yl]acetate (1528534-36-2) → (R)-2-[1-(Biphenyl-4-ylmethyl)-4-(cyclohexylmethyl)piperazin-2-yl]ethanol (1528534-19-1)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 16.17h; Inert atmosphere; Reflux;

DOI:10.1021/jm401707t

Reference yield:

dimethyl (R)-2-[N-(biphenyl-4-ylmethyl)-N-(2-chloroacetyl)amino]butanedioate → (R)-2-[1-(Biphenyl-4-ylmethyl)-4-(cyclohexylmethyl)piperazin-2-yl]ethanol (1528534-19-1)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / acetonitrile / 16 h / 20 °C / Molecular sieve

2: lithium aluminium tetrahydride / tetrahydrofuran / 16.17 h / 0 °C / Inert atmosphere; Reflux

With lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran; acetonitrile;

DOI:10.1021/jm401707t

upstream raw materials:

methyl (R)-2-[1-(biphenyl-4-ylmethyl)-4-(cyclohexylmethyl)-3,6-dioxopiperazin-2-yl]acetate