4-chloro-N²,N⁶-bis[(1R)-2-hydroxy-1-phenylethyl]pyridine-2,6-dicarboxamide

Base Information

Chemical Name:4-chloro-N²,N⁶-bis[(1R)-2-hydroxy-1-phenylethyl]pyridine-2,6-dicarboxamide
CAS No.:1082739-11-4
Molecular Formula:C₂₃H₂₂ClN₃O₄
Molecular Weight:439.898
Hs Code.:

4-chloro-N<sup>2</sup>,N<sup>6</sup>-bis[(1R)-2-hydroxy-1-phenylethyl]pyridine-2,6-dicarboxamide

Synonyms:4-chloro-N²,N⁶-bis[(1R)-2-hydroxy-1-phenylethyl]pyridine-2,6-dicarboxamide

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Chemical Property of 4-chloro-N²,N⁶-bis[(1R)-2-hydroxy-1-phenylethyl]pyridine-2,6-dicarboxamide

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Technology Process of 4-chloro-N²,N⁶-bis[(1R)-2-hydroxy-1-phenylethyl]pyridine-2,6-dicarboxamide

There total 4 articles about 4-chloro-N²,N⁶-bis[(1R)-2-hydroxy-1-phenylethyl]pyridine-2,6-dicarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 71022-75-8
4-chloropyridine-2,6-dicarbonyl dichloride

: 56613-80-0
D-2-phenylglycinol

: 1082739-11-4
4-chloro-N²,N⁶-bis[(1R)-2-hydroxy-1-phenylethyl]pyridine-2,6-dicarboxamide

Guidance literature:: With triethylamine; In acetonitrile; at 75 ℃; for 0.333333h; under 5171.62 Torr;
DOI:10.1055/s-0031-1289676

Reference yield:

: 499-51-4
Chelidamic acid

: 1082739-11-4
4-chloro-N²,N⁶-bis[(1R)-2-hydroxy-1-phenylethyl]pyridine-2,6-dicarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: Vilsmeier reagent; triethylamine; N,N-dimethyl-formamide / acetonitrile / 0.95 h / 75 °C / 5171.62 Torr

2: triethylamine / acetonitrile / 0.33 h / 75 °C / 5171.62 Torr

With Vilsmeier reagent; triethylamine; N,N-dimethyl-formamide; In acetonitrile;
DOI:10.1055/s-0031-1289676

Reference yield:

: 99-32-1
chelidonic acid

: 1082739-11-4
4-chloro-N²,N⁶-bis[(1R)-2-hydroxy-1-phenylethyl]pyridine-2,6-dicarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: ammonium hydroxide / 4.5 h / 45 °C / 3878.71 Torr / Sonication

2: Vilsmeier reagent; triethylamine; N,N-dimethyl-formamide / acetonitrile / 0.95 h / 75 °C / 5171.62 Torr

3: triethylamine / acetonitrile / 0.33 h / 75 °C / 5171.62 Torr

With ammonium hydroxide; Vilsmeier reagent; triethylamine; N,N-dimethyl-formamide; In acetonitrile;
DOI:10.1055/s-0031-1289676