N-{2-[2-amino-4-(1,3-dihydroisoindole-2-carbonyl)quinazolin-6-yl]-4,5-difluorobenzyl}-3-dimethylaminopropionamide

Base Information

Chemical Name:N-{2-[2-amino-4-(1,3-dihydroisoindole-2-carbonyl)quinazolin-6-yl]-4,5-difluorobenzyl}-3-dimethylaminopropionamide
CAS No.:1367454-82-7
Molecular Formula:C₂₉H₂₈F₂N₆O₂
Molecular Weight:530.577
Hs Code.:

Synonyms:N-{2-[2-amino-4-(1,3-dihydroisoindole-2-carbonyl)quinazolin-6-yl]-4,5-difluorobenzyl}-3-dimethylaminopropionamide

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Chemical Property of N-{2-[2-amino-4-(1,3-dihydroisoindole-2-carbonyl)quinazolin-6-yl]-4,5-difluorobenzyl}-3-dimethylaminopropionamide

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Technology Process of N-{2-[2-amino-4-(1,3-dihydroisoindole-2-carbonyl)quinazolin-6-yl]-4,5-difluorobenzyl}-3-dimethylaminopropionamide

There total 9 articles about N-{2-[2-amino-4-(1,3-dihydroisoindole-2-carbonyl)quinazolin-6-yl]-4,5-difluorobenzyl}-3-dimethylaminopropionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: 1367454-80-5
[2-amino-6-(2-aminomethyl-4,5-difluorophenyl)quinazolin-4-yl]-(1,3-dihydroisoindol-2-yl)methanone

: 14788-12-6
3-(dimethylamino)propanoic acid hydrochloride

: 1367454-82-7
N-{2-[2-amino-4-(1,3-dihydroisoindole-2-carbonyl)quinazolin-6-yl]-4,5-difluorobenzyl}-3-dimethylaminopropionamide

Guidance literature:: With 4-methyl-morpholine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; In N,N-dimethyl-formamide; at 22 ℃; for 16h;

Reference yield:

: 1367454-79-2
tert-butyl {2-[2-amino-4-(1,3-dihydroisoindole-2-carbonyl)quinazolin-6-yl]-4,5-difluorobenzyl}biscarbamate

: 1367454-82-7
N-{2-[2-amino-4-(1,3-dihydroisoindole-2-carbonyl)quinazolin-6-yl]-4,5-difluorobenzyl}-3-dimethylaminopropionamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / water; 1,4-dioxane / 1 h / 25 °C

2: 4-methyl-morpholine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 16 h / 22 °C

With 4-methyl-morpholine; hydrogenchloride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; In 1,4-dioxane; water; N,N-dimethyl-formamide;

Reference yield:

: 1228311-57-6
[2-amino-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)quinazolin-4-yl]-(1,3-dihydroisoindol-2-yl)methanone

: 1367454-82-7
N-{2-[2-amino-4-(1,3-dihydroisoindole-2-carbonyl)quinazolin-6-yl]-4,5-difluorobenzyl}-3-dimethylaminopropionamide

Guidance literature:: Multi-step reaction with 5 steps

1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / ethanol; water / 0.5 h / 120 °C / Inert atmosphere

2: thionyl chloride / dichloromethane / 2 h / 25 °C

3: butanone; lithium iodide; caesium carbonate / 3 h / 70 °C

4: hydrogenchloride / water; 1,4-dioxane / 1 h / 25 °C

5: 4-methyl-morpholine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 16 h / 22 °C

With 4-methyl-morpholine; hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; thionyl chloride; potassium carbonate; caesium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; butanone; lithium iodide; In 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; 1: |Suzuki Coupling;