tert-butyl {2-[2-amino-4-(1,3-dihydroisoindole-2-carbonyl)quinazolin-6-yl]-4,5-difluorobenzyl}biscarbamate

Base Information

Chemical Name:tert-butyl {2-[2-amino-4-(1,3-dihydroisoindole-2-carbonyl)quinazolin-6-yl]-4,5-difluorobenzyl}biscarbamate
CAS No.:1367454-79-2
Molecular Formula:C₃₄H₃₅F₂N₅O₅
Molecular Weight:631.679
Hs Code.:

Synonyms:tert-butyl {2-[2-amino-4-(1,3-dihydroisoindole-2-carbonyl)quinazolin-6-yl]-4,5-difluorobenzyl}biscarbamate

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Chemical Property of tert-butyl {2-[2-amino-4-(1,3-dihydroisoindole-2-carbonyl)quinazolin-6-yl]-4,5-difluorobenzyl}biscarbamate

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Technology Process of tert-butyl {2-[2-amino-4-(1,3-dihydroisoindole-2-carbonyl)quinazolin-6-yl]-4,5-difluorobenzyl}biscarbamate

There total 7 articles about tert-butyl {2-[2-amino-4-(1,3-dihydroisoindole-2-carbonyl)quinazolin-6-yl]-4,5-difluorobenzyl}biscarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 51779-32-9
iminodicarboxylic acid di-tert-butyl ester

: 1367455-82-0
[2-amino-6-(2-chloromethyl-4,5-difluorophenyl)quinazolin-4-yl]-(1,3-dihydroisoindol-2-yl)methanone

: 1367454-79-2
tert-butyl {2-[2-amino-4-(1,3-dihydroisoindole-2-carbonyl)quinazolin-6-yl]-4,5-difluorobenzyl}biscarbamate

Guidance literature:: With caesium carbonate; butanone; lithium iodide; at 70 ℃; for 3h;

Reference yield:

: 1228311-57-6
[2-amino-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)quinazolin-4-yl]-(1,3-dihydroisoindol-2-yl)methanone

: 1367454-79-2
tert-butyl {2-[2-amino-4-(1,3-dihydroisoindole-2-carbonyl)quinazolin-6-yl]-4,5-difluorobenzyl}biscarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / ethanol; water / 0.5 h / 120 °C / Inert atmosphere

2: thionyl chloride / dichloromethane / 2 h / 25 °C

3: butanone; lithium iodide; caesium carbonate / 3 h / 70 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; thionyl chloride; potassium carbonate; caesium carbonate; butanone; lithium iodide; In ethanol; dichloromethane; water; 1: |Suzuki Coupling;

Reference yield:

: 20780-76-1
5-iodoisatin

: 1367454-79-2
tert-butyl {2-[2-amino-4-(1,3-dihydroisoindole-2-carbonyl)quinazolin-6-yl]-4,5-difluorobenzyl}biscarbamate

Guidance literature:: Multi-step reaction with 7 steps

1: tetrahydrofuran / 16 h / 10 - 23 °C

2: tetrahydrofuran / 0.5 h / 25 °C

3: cesium fluoride / acetonitrile / 0.33 h / 20 °C / Inert atmosphere

4: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 1 h / 80 °C / Inert atmosphere

5: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / ethanol; water / 0.5 h / 120 °C / Inert atmosphere

6: thionyl chloride / dichloromethane / 2 h / 25 °C

7: butanone; lithium iodide; caesium carbonate / 3 h / 70 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; thionyl chloride; potassium acetate; potassium carbonate; caesium carbonate; cesium fluoride; butanone; lithium iodide; In tetrahydrofuran; ethanol; dichloromethane; water; dimethyl sulfoxide; acetonitrile; 5: |Suzuki Coupling;