(S)-1-(2,5-dioxoazolidinyloxycarbonyloxy)-2-methylpropyl 2-methylpropanate

Base Information

Chemical Name:(S)-1-(2,5-dioxoazolidinyloxycarbonyloxy)-2-methylpropyl 2-methylpropanate
CAS No.:1174524-50-5
Molecular Formula:C₁₃H₁₉NO₇
Molecular Weight:301.296
Hs Code.:

Synonyms:(S)-1-(2,5-dioxoazolidinyloxycarbonyloxy)-2-methylpropyl 2-methylpropanate

Suppliers and Price of (S)-1-(2,5-dioxoazolidinyloxycarbonyloxy)-2-methylpropyl 2-methylpropanate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemicals and raw materials
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Total 2 raw suppliers

Chemical Property of (S)-1-(2,5-dioxoazolidinyloxycarbonyloxy)-2-methylpropyl 2-methylpropanate

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

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Technology Process of (S)-1-(2,5-dioxoazolidinyloxycarbonyloxy)-2-methylpropyl 2-methylpropanate

There total 5 articles about (S)-1-(2,5-dioxoazolidinyloxycarbonyloxy)-2-methylpropyl 2-methylpropanate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 6066-82-6
1-hydroxy-pyrrolidine-2,5-dione

: 1174524-49-2
(S)-isopropyl-(methylthiocarbonyloxy)methyl 2-methylpropionate

: 1174524-50-5
(S)-1-(2,5-dioxoazolidinyloxycarbonyloxy)-2-methylpropyl 2-methylpropanate

Guidance literature:: 1-hydroxy-pyrrolidine-2,5-dione; (S)-isopropyl-(methylthiocarbonyloxy)methyl 2-methylpropionate; With sulfuryl dichloride; In dichloromethane; at -25 - -15 ℃; for 2.5h; Large scale;

With triethylamine; In dichloromethane; at -25 - -15 ℃; for 1h; Large scale;
DOI:10.1021/acs.oprd.0c00491

Reference yield:

: 92600-11-8
1-Chloro-2-Methylpropyl Chloroformate

: 1174524-50-5
(S)-1-(2,5-dioxoazolidinyloxycarbonyloxy)-2-methylpropyl 2-methylpropanate

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetra(n-butyl)ammonium hydrogensulfate / water; dichloromethane / 10.25 h / 0 - 10 °C / Large scale

2.1: potassium carbonate; triethylamine / water; dichloromethane / 15 h / 108 °C / Large scale

3.1: ammonium hydroxide / water; aq. phosphate buffer / 5.5 h / 35 °C / pH 7.5 / Resolution of racemate; Inert atmosphere; Large scale; Enzymatic reaction

4.1: sulfuryl dichloride / dichloromethane / 2.5 h / -25 - -15 °C / Large scale

4.2: 1 h / -25 - -15 °C / Large scale

With ammonium hydroxide; sulfuryl dichloride; tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; triethylamine; In aq. phosphate buffer; dichloromethane; water;
DOI:10.1021/acs.oprd.0c00491

Reference yield:

: 847353-25-7
O-(1-chloroisobutyl)-S-methyl thiocarbonate

: 1174524-50-5
(S)-1-(2,5-dioxoazolidinyloxycarbonyloxy)-2-methylpropyl 2-methylpropanate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate; triethylamine / water; dichloromethane / 15 h / 108 °C / Large scale

2.1: ammonium hydroxide / water; aq. phosphate buffer / 5.5 h / 35 °C / pH 7.5 / Resolution of racemate; Inert atmosphere; Large scale; Enzymatic reaction

3.1: sulfuryl dichloride / dichloromethane / 2.5 h / -25 - -15 °C / Large scale

3.2: 1 h / -25 - -15 °C / Large scale

With ammonium hydroxide; sulfuryl dichloride; potassium carbonate; triethylamine; In aq. phosphate buffer; dichloromethane; water;
DOI:10.1021/acs.oprd.0c00491