(E)-1-(3,9-Difluoro-6,11-dihydrodibenzoxepin-11-yl)-4-(3-phenyl-2-propenyl)piperazine dimaleate

Base Information

Chemical Name:(E)-1-(3,9-Difluoro-6,11-dihydrodibenzoxepin-11-yl)-4-(3-phenyl-2-propenyl)piperazine dimaleate
CAS No.:114312-33-3
Molecular Formula:2C₄H₄O₄*C₂₇H₂₆F₂N₂O
Molecular Weight:664.66
Hs Code.:

(E)-1-(3,9-Difluoro-6,11-dihydrodibenz<b,e>oxepin-11-yl)-4-(3-phenyl-2-propenyl)piperazine dimaleate

Synonyms:(E)-1-(3,9-Difluoro-6,11-dihydrodibenzoxepin-11-yl)-4-(3-phenyl-2-propenyl)piperazine dimaleate

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Chemical Property of (E)-1-(3,9-Difluoro-6,11-dihydrodibenzoxepin-11-yl)-4-(3-phenyl-2-propenyl)piperazine dimaleate

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Technology Process of (E)-1-(3,9-Difluoro-6,11-dihydrodibenzoxepin-11-yl)-4-(3-phenyl-2-propenyl)piperazine dimaleate

There total 6 articles about (E)-1-(3,9-Difluoro-6,11-dihydrodibenzoxepin-11-yl)-4-(3-phenyl-2-propenyl)piperazine dimaleate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 18903-01-0,114312-65-1,87179-40-6
trans-1-cinnamylpiperazine

: 11-Chloro-3,9-difluoro-6,11-dihydro-dibenzo[b,e]oxepine

: 114312-33-3
(E)-1-(3,9-Difluoro-6,11-dihydrodibenzoxepin-11-yl)-4-(3-phenyl-2-propenyl)piperazine dimaleate

Guidance literature:: In dichloromethane; for 1h; Ambient temperature;
DOI:10.1248/cpb.39.2564

Reference yield:

: 23932-84-5
6-fluoroisobenzofuran-1(3H)-one

: 114312-33-3
(E)-1-(3,9-Difluoro-6,11-dihydrodibenzoxepin-11-yl)-4-(3-phenyl-2-propenyl)piperazine dimaleate

Guidance literature:: Multi-step reaction with 5 steps

1: 1 h / 200 °C

2: 80 percent / (CF₃CO)2O, BF₃*Et₂O / CH₂Cl₂ / 1 h / Ambient temperature

3: NaBH₄ / methanol / 0.33 h / 0 °C

4: SOCl₂ / 0.17 h / Ambient temperature

5: 39 percent / CH₂Cl₂ / 1 h / Ambient temperature

With sodium tetrahydroborate; thionyl chloride; boron trifluoride diethyl etherate; trifluoroacetic anhydride; In methanol; dichloromethane;
DOI:10.1248/cpb.39.2564

Reference yield:

: 35535-79-6
sodium m-fluoro phenoxide

: 114312-33-3
(E)-1-(3,9-Difluoro-6,11-dihydrodibenzoxepin-11-yl)-4-(3-phenyl-2-propenyl)piperazine dimaleate

Guidance literature:: Multi-step reaction with 5 steps

1: 1 h / 200 °C

2: 80 percent / (CF₃CO)2O, BF₃*Et₂O / CH₂Cl₂ / 1 h / Ambient temperature

3: NaBH₄ / methanol / 0.33 h / 0 °C

4: SOCl₂ / 0.17 h / Ambient temperature

5: 39 percent / CH₂Cl₂ / 1 h / Ambient temperature

With sodium tetrahydroborate; thionyl chloride; boron trifluoride diethyl etherate; trifluoroacetic anhydride; In methanol; dichloromethane;
DOI:10.1248/cpb.39.2564