4-(3-phenyl-6-trifluoromethyl-quinoxalin-2-yloxy)-benzoic acid methyl ester

Base Information

• Chemical Name: 4-(3-phenyl-6-trifluoromethyl-quinoxalin-2-yloxy)-benzoic acid methyl ester
• CAS No.: 219555-63-2
• Molecular Formula: C₂₃H₁₅F₃N₂O₃
• Molecular Weight: 424.379
• Mol file: 219555-63-2.mol

Synonyms:4-(3-phenyl-6-trifluoromethyl-quinoxalin-2-yloxy)-benzoic acid methyl ester

Chemical Property of 4-(3-phenyl-6-trifluoromethyl-quinoxalin-2-yloxy)-benzoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 4-(3-phenyl-6-trifluoromethyl-quinoxalin-2-yloxy)-benzoic acid methyl ester

There total 1 articles about 4-(3-phenyl-6-trifluoromethyl-quinoxalin-2-yloxy)-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

methyl 4-hydroxylbenzoate (99-76-3,156291-94-0) + 2-chloro-3-phenyl-6-trifluoromethylquinoxaline (102729-52-2) → 4-(3-phenyl-6-trifluoromethyl-quinoxalin-2-yloxy)-benzoic acid methyl ester (219555-63-2)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 70 ℃; for 13h;

DOI:10.1016/S0014-827X(98)00054-8

Reference yield: 50.0%

4-(3-phenyl-6-trifluoromethyl-quinoxalin-2-yloxy)-benzoic acid methyl ester (219555-63-2) → 3-Phenyl-6-trifluoromethylquinoxalinyl-1H-2-one (102729-51-1) + 2-Ethoxy-3-phenyl-6-trifluoromethylquinoxaline

Guidance literature:

With sodium hydroxide; water; In ethanol; at 70 - 75 ℃; for 24h;

DOI:10.1016/S0014-827X(98)00054-8

Reference yield: 45.0%

ethanol (64-17-5) + 4-(3-phenyl-6-trifluoromethyl-quinoxalin-2-yloxy)-benzoic acid methyl ester (219555-63-2) → 3-Phenyl-6-trifluoromethylquinoxalinyl-1H-2-one (102729-51-1) + 2-Ethoxy-3-phenyl-6-trifluoromethylquinoxaline

Guidance literature:

With sodium hydroxide; water; at 70 - 75 ℃; for 24h;

DOI:10.1016/S0014-827X(98)00054-8

upstream raw materials:

methyl 4-hydroxylbenzoate

2-chloro-3-phenyl-6-trifluoromethylquinoxaline

Downstream raw materials:

3-Phenyl-6-trifluoromethylquinoxalinyl-1H-2-one