benzyl 4-(methoxycarbonyl)phenethylcarbamate

Base Information

• Chemical Name: benzyl 4-(methoxycarbonyl)phenethylcarbamate
• CAS No.: 958891-65-1
• Molecular Formula: C₁₈H₁₉NO₄
• Molecular Weight: 313.353
• Mol file: 958891-65-1.mol

Synonyms:benzyl 4-(methoxycarbonyl)phenethylcarbamate

Chemical Property of benzyl 4-(methoxycarbonyl)phenethylcarbamate

Chemical Property:

Purity/Quality:

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Technology Process of benzyl 4-(methoxycarbonyl)phenethylcarbamate

There total 2 articles about benzyl 4-(methoxycarbonyl)phenethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

benzyl (2-(trifluoro-λ4-boraneyl)ethyl)carbamate, potassium salt + 4-methoxycarbonylphenyl bromide (619-42-1) → benzyl 4-(methoxycarbonyl)phenethylcarbamate (958891-65-1)

Guidance literature:

With caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In water; toluene; at 80 ℃; for 12h;

DOI:10.1021/jo7015955

Reference yield: 77.0%

4-(2-aminoethyl)-benzoic acid methyl ester-hydrochloride (56161-89-8) + benzyl chloroformate (501-53-1,94274-21-2) → benzyl 4-(methoxycarbonyl)phenethylcarbamate (958891-65-1)

Guidance literature:

With sodium hydrogencarbonate; In tetrahydrofuran; water; at 20 ℃; for 1.5h;

Reference yield: 72.0%

benzyl 4-(methoxycarbonyl)phenethylcarbamate (958891-65-1) + methyl iodide (74-88-4) → 4-(2-((benzyloxycarbonyl)(methyl)amino)ethyl)benzoic acid (1175530-39-8)

Guidance literature:

benzyl 4-(methoxycarbonyl)phenethylcarbamate; methyl iodide; With sodium hydride; In tetrahydrofuran; at 20 ℃;

With water; at 20 ℃; for 1h;

upstream raw materials:

4-methoxycarbonylphenyl bromide

4-(2-aminoethyl)-benzoic acid methyl ester-hydrochloride

benzyl chloroformate

Downstream raw materials:

4-(2-((benzyloxycarbonyl)(methyl)amino)ethyl)benzoic acid