7-[9-methyl-3-(3-trifluoromethoxy-phenyl)-8,9-dihydro-7H-6-oxa-1,2,3a,4,9-pentaaza-cyclopenta[a]naphthalen-5-yl]-7-aza-spiro[3.5]non-2-ylamine

Base Information

Chemical Name:7-[9-methyl-3-(3-trifluoromethoxy-phenyl)-8,9-dihydro-7H-6-oxa-1,2,3a,4,9-pentaaza-cyclopenta[a]naphthalen-5-yl]-7-aza-spiro[3.5]non-2-ylamine
CAS No.:1313802-10-6
Molecular Formula:C₂₃H₂₆F₃N₇O₂
Molecular Weight:489.5
Hs Code.:

Synonyms:7-[9-methyl-3-(3-trifluoromethoxy-phenyl)-8,9-dihydro-7H-6-oxa-1,2,3a,4,9-pentaaza-cyclopenta[a]naphthalen-5-yl]-7-aza-spiro[3.5]non-2-ylamine

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Chemical Property of 7-[9-methyl-3-(3-trifluoromethoxy-phenyl)-8,9-dihydro-7H-6-oxa-1,2,3a,4,9-pentaaza-cyclopenta[a]naphthalen-5-yl]-7-aza-spiro[3.5]non-2-ylamine

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Technology Process of 7-[9-methyl-3-(3-trifluoromethoxy-phenyl)-8,9-dihydro-7H-6-oxa-1,2,3a,4,9-pentaaza-cyclopenta[a]naphthalen-5-yl]-7-aza-spiro[3.5]non-2-ylamine

There total 4 articles about 7-[9-methyl-3-(3-trifluoromethoxy-phenyl)-8,9-dihydro-7H-6-oxa-1,2,3a,4,9-pentaaza-cyclopenta[a]naphthalen-5-yl]-7-aza-spiro[3.5]non-2-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1239319-82-4
2-amino-7-aza-spiro[3.5]nonane-7-carboxylic acid tert-butyl ester

: 1313733-32-2
5-chloro-9-methyl-3-(3-trifluoromethoxy-phenyl)-8,9-dihydro-7H-6-oxa-1,2,3a,4,9-pentaaza-cyclopenta[a]naphthalene

: 1313802-10-6
7-[9-methyl-3-(3-trifluoromethoxy-phenyl)-8,9-dihydro-7H-6-oxa-1,2,3a,4,9-pentaaza-cyclopenta[a]naphthalen-5-yl]-7-aza-spiro[3.5]non-2-ylamine

: 1313802-09-3
(7-aza-spiro[3.5]non-2-yl)-[9-methyl-3-(3-trifluoromethoxy-phenyl)-8,9-dihydro-7H-6-oxa-1,2,3a,4,9-pentaaza-cyclopenta[a]naphthalen-5-yl]-amine

Guidance literature:: In butan-1-ol; at 180 - 185 ℃; Microwave irradiation;

Reference yield:

: 66643-51-4
3,4-dichloro-5-<(2-hydroxyethyl)methylamino>-pyridazine

: 1313802-10-6
7-[9-methyl-3-(3-trifluoromethoxy-phenyl)-8,9-dihydro-7H-6-oxa-1,2,3a,4,9-pentaaza-cyclopenta[a]naphthalen-5-yl]-7-aza-spiro[3.5]non-2-ylamine

: 1313802-09-3
(7-aza-spiro[3.5]non-2-yl)-[9-methyl-3-(3-trifluoromethoxy-phenyl)-8,9-dihydro-7H-6-oxa-1,2,3a,4,9-pentaaza-cyclopenta[a]naphthalen-5-yl]-amine

Guidance literature:: Multi-step reaction with 4 steps

1: potassium tert-butylate / tetrahydrofuran / Reflux

2: NCS / acetonitrile / 3 h / 50 °C

3: butan-1-ol / 1.5 h / 185 °C / Microwave irradiation

4: butan-1-ol / 180 - 185 °C / Microwave irradiation

With potassium tert-butylate; In tetrahydrofuran; acetonitrile; butan-1-ol;

Reference yield:

: 66643-52-5
8-chloro-3,4-dihydro-4-methyl-2H-pyridazino<4,5-b>-1,4-oxazine

: 1313802-10-6
7-[9-methyl-3-(3-trifluoromethoxy-phenyl)-8,9-dihydro-7H-6-oxa-1,2,3a,4,9-pentaaza-cyclopenta[a]naphthalen-5-yl]-7-aza-spiro[3.5]non-2-ylamine

: 1313802-09-3
(7-aza-spiro[3.5]non-2-yl)-[9-methyl-3-(3-trifluoromethoxy-phenyl)-8,9-dihydro-7H-6-oxa-1,2,3a,4,9-pentaaza-cyclopenta[a]naphthalen-5-yl]-amine

Guidance literature:: Multi-step reaction with 3 steps

1: NCS / acetonitrile / 3 h / 50 °C

2: butan-1-ol / 1.5 h / 185 °C / Microwave irradiation

3: butan-1-ol / 180 - 185 °C / Microwave irradiation

With NCS; In acetonitrile; butan-1-ol;