tert-Butyl 2-amino-7-azaspiro[3.5]nonane-7-carboxylate

Base Information

• Chemical Name: tert-Butyl 2-amino-7-azaspiro[3.5]nonane-7-carboxylate
• CAS No.: 1239319-82-4
• Molecular Formula: C16H27NO4
• Molecular Weight: 240.346
• Hs Code.: 2933990090
• European Community (EC) Number: 840-557-4
• DSSTox Substance ID: DTXSID60704072
• Mol file: 1239319-82-4.mol

Synonyms:1239319-82-4;tert-Butyl 2-amino-7-azaspiro[3.5]nonane-7-carboxylate;2-AMINO-7-AZASPIRO[3.5]NONANE-7-CARBOXYLIC ACID TERT-BUTYL ESTER;2-Amino-7-Boc-7-azaspiro[3.5]nonane;2-AMino-7-Boc-7-azaspiro[...;MFCD14581153;7-Boc-2-amino-7-azaspiro[3.5]nonane;2-Amino-7-aza-spiro[3.5]nonane-7-carboxylic acid tert-butyl ester;2-Amino-7-azaspiro[3.5]nonane-7-carboxylic acid tert-butyl ester;2-Amino7-Boc-7-azaspiro[3.5]nonane;SCHEMBL623537;tert-Butyl2-amino-7-azaspiro[3.5]nonane-7-carboxylate;DTXSID60704072;DICPJODHTVCFGU-UHFFFAOYSA-N;AKOS015950390;DS-6078;PB24161;SY096869;AM20070578;FT-0685980;EN300-64079;A852827;J-508014;W-205182;2-Amino-7-azaspiro[3.5]nonane-7-carboxylic acid tert-butyl ester 95+%;7-Azaspiro[3.5]nonane-7-carboxylic acid, 2-amino-, 1,1-dimethylethyl ester

Chemical Property of tert-Butyl 2-amino-7-azaspiro[3.5]nonane-7-carboxylate

Chemical Property:

• Boiling Point: 336.5±42.0 °C(Predicted)
• PKA: 10?+-.0.20(Predicted)
• PSA: 55.56000
• Density: 1.08±0.1 g/cm3(Predicted)
• LogP: 2.76300
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 240.183778013
• Heavy Atom Count: 17
• Complexity: 293

Purity/Quality:

98%,99%, ^*data from raw suppliers

tert-Butyl2-Amino-7-azaspiro[3.5]nonane-7-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)N1CCC2(CC1)CC(C2)N

Technology Process of tert-Butyl 2-amino-7-azaspiro[3.5]nonane-7-carboxylate

There total 7 articles about tert-Butyl 2-amino-7-azaspiro[3.5]nonane-7-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-azido-7-azaspiro[3.5]nonane-7-carboxylic acid tert-butyl ester (1239319-81-3) → 2-amino-7-aza-spiro[3.5]nonane-7-carboxylic acid tert-butyl ester (1239319-82-4)

Guidance literature:

With hydrogen; Lindlar catalyst; In ethanol; at 20 ℃; for 5h; under 1034.32 Torr;

Reference yield:

tert-butyl 2-(hydroxyimino)-7-azaspiro[3.5]nonane-7-carboxylate (1239320-24-1) → 2-amino-7-aza-spiro[3.5]nonane-7-carboxylic acid tert-butyl ester (1239319-82-4)

Guidance literature:

With ammonia; hydrogen; Raney nickel; In methanol; at 20 ℃; for 2.5h; under 1034.32 Torr;

Reference yield:

tert-butyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate (203661-69-2) → 2-amino-7-aza-spiro[3.5]nonane-7-carboxylic acid tert-butyl ester (1239319-82-4)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate; hydroxylamine hydrochloride / ethanol / 12 h / 20 °C

2: hydrogen; ammonia / Raney nickel / methanol / 2.5 h / 20 °C / 1034.32 Torr

With hydroxylamine hydrochloride; ammonia; hydrogen; potassium carbonate; Raney nickel; In methanol; ethanol;

upstream raw materials:

tert-butyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate

tert-butyl 2-(hydroxyimino)-7-azaspiro[3.5]nonane-7-carboxylate

2-((methylsulfonyl)oxy)-7-azaspiro[3.5]nonane-7-carboxylic acid tert-butyl ester

2-azido-7-azaspiro[3.5]nonane-7-carboxylic acid tert-butyl ester

Downstream raw materials:

tert-Butyl 2-(4-nitrophenoxycarbonylamino)-7-azaspiro[3.5]nonane-7-carboxylate

3-carbamoylisoxazol-5-ylmethyl{7-[5-(4-fluorophenyl)pyridin-2-yl]-7-azaspiro[3.5]non-2-yl}carbamate

Refernces

• 1、 -. "DERIVATIVES OF AZASPIRANYL-ALKYLCARBAMATES OF 5-MEMBER HETEROCYCLIC COMPOUNDS, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF". . . Retrieved 2012/01/13.