2-(4-hydroxyphenyl)-1-(4-((S)-2-((R)-3-methylpyrrolidin-1-yl)propoxy)phenyl)-2,3-dihydro-1H-inden-5-ol

Base Information

• Chemical Name: 2-(4-hydroxyphenyl)-1-(4-((S)-2-((R)-3-methylpyrrolidin-1-yl)propoxy)phenyl)-2,3-dihydro-1H-inden-5-ol
• CAS No.: 1352546-95-2
• Molecular Formula: C₂₉H₃₃NO₃
• Molecular Weight: 443.586
• Mol file: 1352546-95-2.mol

Synonyms:2-(4-hydroxyphenyl)-1-(4-((S)-2-((R)-3-methylpyrrolidin-1-yl)propoxy)phenyl)-2,3-dihydro-1H-inden-5-ol

Chemical Property of 2-(4-hydroxyphenyl)-1-(4-((S)-2-((R)-3-methylpyrrolidin-1-yl)propoxy)phenyl)-2,3-dihydro-1H-inden-5-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-hydroxyphenyl)-1-(4-((S)-2-((R)-3-methylpyrrolidin-1-yl)propoxy)phenyl)-2,3-dihydro-1H-inden-5-ol

There total 12 articles about 2-(4-hydroxyphenyl)-1-(4-((S)-2-((R)-3-methylpyrrolidin-1-yl)propoxy)phenyl)-2,3-dihydro-1H-inden-5-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3R)-1-((2S)-1-(4-(5-methoxy-2-(4-methoxyphenyl)-2,3-dihydro-1H-inden-1-yl)phenoxy)propan-2-yl)-3-methylpyrrolidine (1352547-08-0) → 2-(4-hydroxyphenyl)-1-(4-((S)-2-((R)-3-methylpyrrolidin-1-yl)propoxy)phenyl)-2,3-dihydro-1H-inden-5-ol (1352546-95-2)

Guidance literature:

(3R)-1-((2S)-1-(4-(5-methoxy-2-(4-methoxyphenyl)-2,3-dihydro-1H-inden-1-yl)phenoxy)propan-2-yl)-3-methylpyrrolidine; With boron tribromide; In dichloromethane; at 0 - 20 ℃; for 1.16667h; Inert atmosphere;

With methanol; In dichloromethane; at 0 ℃;

Reference yield:

m-methoxybenzyl chloride (824-98-6) → 2-(4-hydroxyphenyl)-1-(4-((S)-2-((R)-3-methylpyrrolidin-1-yl)propoxy)phenyl)-2,3-dihydro-1H-inden-5-ol (1352546-95-2)

Guidance literature:

Multi-step reaction with 5 steps

1.1: potassium hexamethylsilazane / tetrahydrofuran / 3.5 h / 20 °C / Inert atmosphere

1.2: 60 h

2.1: methanesulfonic acid / dichloromethane / 5 h / 0 - 20 °C

3.1: potassium carbonate / [2,2]bipyridinyl; copper(l) iodide / m-xylene / 14 h / 140 °C / Inert atmosphere

4.1: hydrogen / palladium 10% on activated carbon / ethyl acetate; ethanol / 47.5 h / 3361.55 Torr

5.1: boron tribromide / dichloromethane / 1.17 h / 0 - 20 °C / Inert atmosphere

5.2: 0 °C

With methanesulfonic acid; hydrogen; boron tribromide; potassium hexamethylsilazane; potassium carbonate; [2,2]bipyridinyl; copper(l) iodide; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; ethyl acetate; m-xylene; 3.1: Ullmann Condensation;

Reference yield:

4-iodobenzoic acid chloride (1711-02-0) → 2-(4-hydroxyphenyl)-1-(4-((S)-2-((R)-3-methylpyrrolidin-1-yl)propoxy)phenyl)-2,3-dihydro-1H-inden-5-ol (1352546-95-2)

Guidance literature:

Multi-step reaction with 7 steps

1.1: sodium carbonate / toluene; water / 2.83 h / 0 °C

2.1: 2-methyltetrahydrofuran / 5.25 h / 0 - 5 °C / Inert atmosphere

3.1: potassium hexamethylsilazane / tetrahydrofuran / 3.5 h / 20 °C / Inert atmosphere

3.2: 60 h

4.1: methanesulfonic acid / dichloromethane / 5 h / 0 - 20 °C

5.1: potassium carbonate / [2,2]bipyridinyl; copper(l) iodide / m-xylene / 14 h / 140 °C / Inert atmosphere

6.1: hydrogen / palladium 10% on activated carbon / ethyl acetate; ethanol / 47.5 h / 3361.55 Torr

7.1: boron tribromide / dichloromethane / 1.17 h / 0 - 20 °C / Inert atmosphere

7.2: 0 °C

With methanesulfonic acid; hydrogen; boron tribromide; potassium hexamethylsilazane; sodium carbonate; potassium carbonate; [2,2]bipyridinyl; copper(l) iodide; palladium 10% on activated carbon; In tetrahydrofuran; 2-methyltetrahydrofuran; ethanol; dichloromethane; water; ethyl acetate; m-xylene; toluene; 5.1: Ullmann Condensation;

upstream raw materials:

m-methoxybenzyl chloride

4-iodobenzoic acid chloride

N,O-Dimethyl-4-iodobenzenehydroxamic acid

(R)-methylsuccinic acid dimethyl ester