(3R)-1-((2S)-1-(4-(5-methoxy-2-(4-methoxyphenyl)-2,3-dihydro-1H-inden-1-yl)phenoxy)propan-2-yl)-3-methylpyrrolidine

Base Information

Chemical Name:(3R)-1-((2S)-1-(4-(5-methoxy-2-(4-methoxyphenyl)-2,3-dihydro-1H-inden-1-yl)phenoxy)propan-2-yl)-3-methylpyrrolidine
CAS No.:1352547-08-0
Molecular Formula:C₃₁H₃₇NO₃
Molecular Weight:471.64
Hs Code.:

Synonyms:(3R)-1-((2S)-1-(4-(5-methoxy-2-(4-methoxyphenyl)-2,3-dihydro-1H-inden-1-yl)phenoxy)propan-2-yl)-3-methylpyrrolidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3R)-1-((2S)-1-(4-(5-methoxy-2-(4-methoxyphenyl)-2,3-dihydro-1H-inden-1-yl)phenoxy)propan-2-yl)-3-methylpyrrolidine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (3R)-1-((2S)-1-(4-(5-methoxy-2-(4-methoxyphenyl)-2,3-dihydro-1H-inden-1-yl)phenoxy)propan-2-yl)-3-methylpyrrolidine

There total 11 articles about (3R)-1-((2S)-1-(4-(5-methoxy-2-(4-methoxyphenyl)-2,3-dihydro-1H-inden-1-yl)phenoxy)propan-2-yl)-3-methylpyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1352547-07-9
(R)-1-((S)-1-(4-(6-methoxy-2-(4-methoxyphenyl)-1H-inden-3-yl)phenoxy)propan-2-yl)-3-methylpyrrolidine

: 1352547-08-0
(3R)-1-((2S)-1-(4-(5-methoxy-2-(4-methoxyphenyl)-2,3-dihydro-1H-inden-1-yl)phenoxy)propan-2-yl)-3-methylpyrrolidine

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethanol; ethyl acetate; for 47.5h; under 3361.55 Torr;

Reference yield:

: 824-98-6
m-methoxybenzyl chloride

: 1352547-08-0
(3R)-1-((2S)-1-(4-(5-methoxy-2-(4-methoxyphenyl)-2,3-dihydro-1H-inden-1-yl)phenoxy)propan-2-yl)-3-methylpyrrolidine

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium hexamethylsilazane / tetrahydrofuran / 3.5 h / 20 °C / Inert atmosphere

1.2: 60 h

2.1: methanesulfonic acid / dichloromethane / 5 h / 0 - 20 °C

3.1: potassium carbonate / [2,2]bipyridinyl; copper(l) iodide / m-xylene / 14 h / 140 °C / Inert atmosphere

4.1: hydrogen / palladium 10% on activated carbon / ethyl acetate; ethanol / 47.5 h / 3361.55 Torr

With methanesulfonic acid; hydrogen; potassium hexamethylsilazane; potassium carbonate; [2,2]bipyridinyl; copper(l) iodide; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; ethyl acetate; m-xylene; 3.1: Ullmann Condensation;

Reference yield:

: 1711-02-0
4-iodobenzoic acid chloride

: 1352547-08-0
(3R)-1-((2S)-1-(4-(5-methoxy-2-(4-methoxyphenyl)-2,3-dihydro-1H-inden-1-yl)phenoxy)propan-2-yl)-3-methylpyrrolidine

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium carbonate / toluene; water / 2.83 h / 0 °C

2.1: 2-methyltetrahydrofuran / 5.25 h / 0 - 5 °C / Inert atmosphere

3.1: potassium hexamethylsilazane / tetrahydrofuran / 3.5 h / 20 °C / Inert atmosphere

3.2: 60 h

4.1: methanesulfonic acid / dichloromethane / 5 h / 0 - 20 °C

5.1: potassium carbonate / [2,2]bipyridinyl; copper(l) iodide / m-xylene / 14 h / 140 °C / Inert atmosphere

6.1: hydrogen / palladium 10% on activated carbon / ethyl acetate; ethanol / 47.5 h / 3361.55 Torr

With methanesulfonic acid; hydrogen; potassium hexamethylsilazane; sodium carbonate; potassium carbonate; [2,2]bipyridinyl; copper(l) iodide; palladium 10% on activated carbon; In tetrahydrofuran; 2-methyltetrahydrofuran; ethanol; dichloromethane; water; ethyl acetate; m-xylene; toluene; 5.1: Ullmann Condensation;