ETHYL 6-FLUORO-4-HYDROXY-3-QUINOLINECARBOXYLATE

Base Information

• Chemical Name: ETHYL 6-FLUORO-4-HYDROXY-3-QUINOLINECARBOXYLATE
• CAS No.: 318-35-4
• Molecular Formula: C12H10FNO3
• Molecular Weight: 235.215
• Hs Code.: 2933499090
• Mol file: 318-35-4.mol

Synonyms:6-Fluoro-4-hydroxyquinoline-3-carboxylicacid ethyl ester;Ethyl 6-fluoro-4-hydroxy-3-quinolinecarboxylate;

Chemical Property of ETHYL 6-FLUORO-4-HYDROXY-3-QUINOLINECARBOXYLATE

Chemical Property:

• Vapor Pressure: 5.2E-05mmHg at 25°C
• Melting Point: 320-323 °C
• Refractive Index: 1.552
• Boiling Point: 348 °C at 760 mmHg
• PKA: 2.40±0.50(Predicted)
• Flash Point: 164.2 °C
• PSA: 59.42000
• Density: 1.318 g/cm³
• LogP: 2.25620
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Ethyl6-fluoro-4-hydroxyquinoline-3-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ETHYL 6-FLUORO-4-HYDROXY-3-QUINOLINECARBOXYLATE

There total 8 articles about ETHYL 6-FLUORO-4-HYDROXY-3-QUINOLINECARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

diethyl 2-(4-fluoroanilino)methylenemalonate (26832-96-2) → ethyl 6-fluoro-4-hydroxy-3-quinoline-carboxylate (318-35-4)

Guidance literature:

at 250 ℃; for 4h;

DOI:10.1016/j.bmcl.2009.12.045

Reference yield: 69.0%

→ ethyl 6-fluoro-4-hydroxy-3-quinoline-carboxylate (318-35-4)

Guidance literature:

Reference yield: 40.0%

ethyl 1-[1-ethoxycarbonyl-2-(4-pyridyl)vinyl]-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate → ethyl 6-fluoro-4-hydroxy-3-quinoline-carboxylate (318-35-4)

Guidance literature:

With hydrazine hydrate; In 1,4-dioxane; N,N-dimethyl-formamide; for 2h; Reflux;

DOI:10.1002/jhet.297

upstream raw materials:

diphenylether

diethyl 2-(4-fluoroanilino)methylenemalonate

diethyl 2-ethoxymethylenemalonate

4-fluoroaniline

Downstream raw materials:

6-fluoro-4-hydroxy-quinoline-3-carboxylic acid

4-chloro-6-fluoroquinoline-3-carboxylic acid ethyl ester