C₁₅H₁₄ClFN₂O₂

Base Information

Chemical Name:C₁₅H₁₄ClFN₂O₂
CAS No.:1403226-61-8
Molecular Formula:C₁₅H₁₄ClFN₂O₂
Molecular Weight:308.74
Hs Code.:

C<sub>15</sub>H<sub>14</sub>ClFN<sub>2</sub>O<sub>2</sub>

Synonyms:C₁₅H₁₄ClFN₂O₂

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Chemical Property of C₁₅H₁₄ClFN₂O₂

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Technology Process of C₁₅H₁₄ClFN₂O₂

There total 8 articles about C₁₅H₁₄ClFN₂O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1175086-67-5
2-[(2-chloro-6-fluorophenyl)amino]-5-methylbenzeneacetic acid methyl ester

: 1403226-61-8
C₁₅H₁₄ClFN₂O₂

Guidance literature:: With potassium cyanide; water; hydroxylamine; In tetrahydrofuran; methanol; at 20 ℃; for 18h;
DOI:10.1002/cmdc.201200272

Reference yield:

: 2941-78-8
2-Amino-5-methylbenzoic acid

: 1403226-61-8
C₁₅H₁₄ClFN₂O₂

Guidance literature:: Multi-step reaction with 7 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene; copper(II) acetate monohydrate / 1,4-dioxane / 25 °C

2: dimethylsulfide borane complex / tetrahydrofuran / 0 °C / Inert atmosphere; Reflux

3: pyridine; thionyl chloride / tetrahydrofuran / 0 - 5 °C

4: dimethyl sulfoxide / 1.5 h / Inert atmosphere

5: water; barium(II) hydroxide / 1,4-dioxane / 30 h / Reflux; Inert atmosphere

6: dmap; dicyclohexyl-carbodiimide / dichloromethane / 0 - 20 °C

7: potassium cyanide; water; hydroxylamine / methanol; tetrahydrofuran / 18 h / 20 °C

With pyridine; dmap; potassium cyanide; thionyl chloride; dimethylsulfide borane complex; water; hydroxylamine; copper(II) acetate monohydrate; 1,8-diazabicyclo[5.4.0]undec-7-ene; dicyclohexyl-carbodiimide; barium(II) hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; dimethyl sulfoxide; 1: |Chan-Lam Coupling;
DOI:10.1002/cmdc.201200272

Reference yield:

: 313545-32-3
(2-chloro-6-fluorophenyl)boronic acid

: 1403226-61-8
C₁₅H₁₄ClFN₂O₂

Guidance literature:: Multi-step reaction with 7 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene; copper(II) acetate monohydrate / 1,4-dioxane / 25 °C

2: dimethylsulfide borane complex / tetrahydrofuran / 0 °C / Inert atmosphere; Reflux

3: pyridine; thionyl chloride / tetrahydrofuran / 0 - 5 °C

4: dimethyl sulfoxide / 1.5 h / Inert atmosphere

5: water; barium(II) hydroxide / 1,4-dioxane / 30 h / Reflux; Inert atmosphere

6: dmap; dicyclohexyl-carbodiimide / dichloromethane / 0 - 20 °C

7: potassium cyanide; water; hydroxylamine / methanol; tetrahydrofuran / 18 h / 20 °C

With pyridine; dmap; potassium cyanide; thionyl chloride; dimethylsulfide borane complex; water; hydroxylamine; copper(II) acetate monohydrate; 1,8-diazabicyclo[5.4.0]undec-7-ene; dicyclohexyl-carbodiimide; barium(II) hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; dimethyl sulfoxide; 1: |Chan-Lam Coupling;
DOI:10.1002/cmdc.201200272