Technology Process of (2E,4E)-3-methyl-5-{6,6-dimethyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolanyl)-1-cyclohexenyl}-2,4-pentadienal
There total 7 articles about (2E,4E)-3-methyl-5-{6,6-dimethyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolanyl)-1-cyclohexenyl}-2,4-pentadienal which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
4-methyl-morpholine; tetrapropylammonium perruthennate;
In
dichloromethane;
at 0 - 20 ℃;
for 1h;
Molecular sieve;
Inert atmosphere;
DOI:10.1016/j.bmcl.2014.05.041
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: sodium hydride / mineral oil; diethyl ether / 0.25 h / 0 °C / Inert atmosphere
1.2: 3 h / 0 °C / Inert atmosphere
2.1: diisobutylaluminium hydride / diethyl ether; hexane / 2.5 h / 0 °C / Inert atmosphere
3.1: 4-methyl-morpholine; tetrapropylammonium perruthennate / dichloromethane / 2 h / 0 - 20 °C / Molecular sieve; Inert atmosphere
4.1: n-butyllithium / hexane; tetrahydrofuran / 0.75 h / -78 °C
4.2: 3 h
5.1: diisobutylaluminium hydride / diethyl ether; hexane / 2.5 h / 0 °C / Inert atmosphere
6.1: bis-triphenylphosphine-palladium(II) chloride; triphenylphosphine; potassium phenolate / toluene / 16 h / 40 °C / Inert atmosphere
7.1: 4-methyl-morpholine; tetrapropylammonium perruthennate / dichloromethane / 1 h / 0 - 20 °C / Molecular sieve; Inert atmosphere
With
4-methyl-morpholine; bis-triphenylphosphine-palladium(II) chloride; n-butyllithium; tetrapropylammonium perruthennate; potassium phenolate; sodium hydride; diisobutylaluminium hydride; triphenylphosphine;
In
tetrahydrofuran; diethyl ether; hexane; dichloromethane; toluene; mineral oil;
6.1: |Miyaura Borylation Reaction;
DOI:10.1016/j.bmcl.2014.05.041
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: diisobutylaluminium hydride / diethyl ether; hexane / 2.5 h / 0 °C / Inert atmosphere
2.1: 4-methyl-morpholine; tetrapropylammonium perruthennate / dichloromethane / 2 h / 0 - 20 °C / Molecular sieve; Inert atmosphere
3.1: n-butyllithium / hexane; tetrahydrofuran / 0.75 h / -78 °C
3.2: 3 h
4.1: diisobutylaluminium hydride / diethyl ether; hexane / 2.5 h / 0 °C / Inert atmosphere
5.1: bis-triphenylphosphine-palladium(II) chloride; triphenylphosphine; potassium phenolate / toluene / 16 h / 40 °C / Inert atmosphere
6.1: 4-methyl-morpholine; tetrapropylammonium perruthennate / dichloromethane / 1 h / 0 - 20 °C / Molecular sieve; Inert atmosphere
With
4-methyl-morpholine; bis-triphenylphosphine-palladium(II) chloride; n-butyllithium; tetrapropylammonium perruthennate; potassium phenolate; diisobutylaluminium hydride; triphenylphosphine;
In
tetrahydrofuran; diethyl ether; hexane; dichloromethane; toluene;
5.1: |Miyaura Borylation Reaction;
DOI:10.1016/j.bmcl.2014.05.041
