(S)-tert-butyl (1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)ethyl)carbamate

Base Information

Chemical Name:(S)-tert-butyl (1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)ethyl)carbamate
CAS No.:1615254-09-5
Molecular Formula:C₂₁H₂₂FN₃O₃
Molecular Weight:383.422
Hs Code.:

Synonyms:(S)-tert-butyl (1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)ethyl)carbamate

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Chemical Property of (S)-tert-butyl (1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)ethyl)carbamate

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Technology Process of (S)-tert-butyl (1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)ethyl)carbamate

There total 9 articles about (S)-tert-butyl (1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)ethyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.6%

: tert-butyl (S)-(1-((3-fluoro-2-(phenylcarbamoyl)phenyl)amino)-1-oxopropan-2-yl)carbamate

: 1615254-09-5
(S)-tert-butyl (1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)ethyl)carbamate

Guidance literature:: With N,O-bis-(trimethylsilyl)-acetamide; triethylamine; In acetonitrile; Inert atmosphere; Reflux;

Reference yield: 20.0%

: 15761-38-3
L-N-Boc-Ala

: 434-76-4
2-amino-6-fluorobenzoic acid

: 62-53-3
aniline

: 1615254-09-5
(S)-tert-butyl (1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)ethyl)carbamate

Guidance literature:: L-N-Boc-Ala; 2-amino-6-fluorobenzoic acid; With pyridine; diphenyl hydrogen phosphite; Inert atmosphere; Heating;

aniline; at 55 ℃; Inert atmosphere;
DOI:10.1016/j.bmc.2021.116312

Reference yield:

: 385-02-4
6-fluoro-2-nitrobenzoic acid

: 1615254-09-5
(S)-tert-butyl (1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)ethyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: thionyl chloride / toluene / 8 h / 110 °C

1.2: 5 - 20 °C

2.1: iron; ammonium formate / water; ethanol / 7 h / 80 °C

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / -10 °C / Reflux

4.1: triethylamine; N,O-bis-(trimethylsilyl)-acetamide / acetonitrile / Inert atmosphere; Reflux

With thionyl chloride; N,O-bis-(trimethylsilyl)-acetamide; ammonium formate; iron; triethylamine; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane; water; toluene; acetonitrile;