2-aMino-6-fluoro-N-phenylbenzaMide hydrochloride

Base Information

• Chemical Name: 2-aMino-6-fluoro-N-phenylbenzaMide hydrochloride
• CAS No.: 1417456-04-2
• Molecular Formula: C₁₃H₁₁FN₂O
• Molecular Weight: 230.242
• Mol file: 1417456-04-2.mol

Synonyms:2-aMino-6-fluoro-N-phenylbenzaMide hydrochloride;2-aMino-6-fluoro-N-phenylbenzaMide;2-Fluoro-6-amino-N-phenylbenzamide

Chemical Property of 2-aMino-6-fluoro-N-phenylbenzaMide hydrochloride

Chemical Property:

• Boiling Point: 320.8±32.0 °C(Predicted)
• PKA: 12.37±0.70(Predicted)
• PSA: 55.12000
• Density: 1.317±0.06 g/cm3(Predicted)
• LogP: 3.31440

Purity/Quality:

99.9% ^*data from raw suppliers

2-Amino-6-fluoro-N-phenylbenzamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Amino-6-fluoro-N-phenylbenzamide is used as reactant/reagent in synthetic preparation of idelalisib using the HMDS/I2-catalyzed cyclocondensation and Boc deprotection of an (aminobutyrylamino)benzamide to a nonracemic quinazoline as the key step. 2-Amino-6-fluoro-N-phenyl-benzamide is obtained from 2-fluoro-6-nitro-benzoic acid.

Technology Process of 2-aMino-6-fluoro-N-phenylbenzaMide hydrochloride

There total 1 articles about 2-aMino-6-fluoro-N-phenylbenzaMide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-amino-6-fluorobenzoic acid (434-76-4) → 2-amino-6-fluoro-N-phenyl-benzamide (1417456-04-2)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / acetonitrile; dichloromethane / 50 - 60 °C

2: acetonitrile / 40 - 82 °C

With pyridine; In dichloromethane; acetonitrile;

Reference yield: 77.0%

2-chloropropionyl chloride (7623-09-8) + 2-amino-6-fluoro-N-phenyl-benzamide (1417456-04-2) → 2-(2-chloropropanamido)-6-fluoro-N-phenylbenzamide

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 1h;

Reference yield:

2-amino-6-fluoro-N-phenyl-benzamide (1417456-04-2) → (S)-[1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydro-quinazolin-2-yl)propyl]carbamic acid isobutyl ester

Guidance literature:

Multi-step reaction with 2 steps

1.1: 4-methyl-morpholine / tetrahydrofuran / 1 h / -15 °C

1.2: 4.5 h / -15 °C / Reflux

2.1: chloro-trimethyl-silane; triethylamine / acetonitrile / 48 h / Inert atmosphere; Sealed tube

With 4-methyl-morpholine; chloro-trimethyl-silane; triethylamine; In tetrahydrofuran; acetonitrile;

upstream raw materials:

2-amino-6-fluorobenzoic acid

Downstream raw materials:

(S)-tert-butyl (1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)ethyl)carbamate

(S)-2-(1-aminoethyl)-5-fluoro-3-phenylquinazolin-4(3H)-one