2-aMino-6-fluoro-N-phenylbenzaMide hydrochloride

Base Information

Chemical Name:2-aMino-6-fluoro-N-phenylbenzaMide hydrochloride
CAS No.:1417456-04-2
Molecular Formula:C₁₃H₁₁FN₂O
Molecular Weight:230.242
Hs Code.:
Mol file:1417456-04-2.mol

Synonyms:2-aMino-6-fluoro-N-phenylbenzaMide hydrochloride;2-aMino-6-fluoro-N-phenylbenzaMide;2-Fluoro-6-amino-N-phenylbenzamide

Suppliers and Price of 2-aMino-6-fluoro-N-phenylbenzaMide hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-Amino-6-fluoro-N-phenylbenzamide
50mg
$ 105.00

TRC
2-Amino-6-fluoro-N-phenylbenzamide
250mg
$ 440.00

Crysdot
2-Amino-6-fluoro-N-phenylbenzamide 95+%
10g
$ 380.00

Alichem
2-Amino-6-fluoro-N-phenylbenzamide
10g
$ 400.00

Acrotein
2-Amino-6-fluoro-N-phenylbenzamide 97%
5g
$ 312.87

Total 33 raw suppliers

Chemical Property of 2-aMino-6-fluoro-N-phenylbenzaMide hydrochloride

Chemical Property:

Boiling Point:320.8±32.0 °C(Predicted)
PKA:12.37±0.70(Predicted)
PSA：55.12000
Density:1.317±0.06 g/cm3(Predicted)
LogP:3.31440

Purity/Quality:

99%, ^*data from raw suppliers

2-Amino-6-fluoro-N-phenylbenzamide ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses 2-Amino-6-fluoro-N-phenylbenzamide is used as reactant/reagent in synthetic preparation of idelalisib using the HMDS/I2-catalyzed cyclocondensation and Boc deprotection of an (aminobutyrylamino)benzamide to a nonracemic quinazoline as the key step. 2-Amino-6-fluoro-N-phenyl-benzamide is obtained from 2-fluoro-6-nitro-benzoic acid.

Technology Process of 2-aMino-6-fluoro-N-phenylbenzaMide hydrochloride

There total 1 articles about 2-aMino-6-fluoro-N-phenylbenzaMide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 434-76-4
2-amino-6-fluorobenzoic acid

: 1417456-04-2
2-amino-6-fluoro-N-phenyl-benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / acetonitrile; dichloromethane / 50 - 60 °C

2: acetonitrile / 40 - 82 °C

With pyridine; In dichloromethane; acetonitrile;

Reference yield: 77.0%

: 7623-09-8
2-chloropropionyl chloride

: 1417456-04-2
2-amino-6-fluoro-N-phenyl-benzamide

: 2-(2-chloropropanamido)-6-fluoro-N-phenylbenzamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 1h;

Reference yield:

: 1417456-04-2
2-amino-6-fluoro-N-phenyl-benzamide

: (S)-[1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydro-quinazolin-2-yl)propyl]carbamic acid isobutyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 4-methyl-morpholine / tetrahydrofuran / 1 h / -15 °C

1.2: 4.5 h / -15 °C / Reflux

2.1: chloro-trimethyl-silane; triethylamine / acetonitrile / 48 h / Inert atmosphere; Sealed tube

With 4-methyl-morpholine; chloro-trimethyl-silane; triethylamine; In tetrahydrofuran; acetonitrile;