3-((4-(4-amino-2-chlorobenzoyl)piperazin-1-yl)methyl)-N-tert-butylbenzamide

Base Information

Chemical Name:3-((4-(4-amino-2-chlorobenzoyl)piperazin-1-yl)methyl)-N-tert-butylbenzamide
CAS No.:1124213-72-4
Molecular Formula:C₂₃H₂₉ClN₄O₂
Molecular Weight:428.962
Hs Code.:

Synonyms:3-((4-(4-amino-2-chlorobenzoyl)piperazin-1-yl)methyl)-N-tert-butylbenzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-((4-(4-amino-2-chlorobenzoyl)piperazin-1-yl)methyl)-N-tert-butylbenzamide

Chemical Property:

Purity/Quality:

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Technology Process of 3-((4-(4-amino-2-chlorobenzoyl)piperazin-1-yl)methyl)-N-tert-butylbenzamide

There total 6 articles about 3-((4-(4-amino-2-chlorobenzoyl)piperazin-1-yl)methyl)-N-tert-butylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1124213-70-2
N-tert-butyl-3-((4-(2-chloro-4-nitrobenzoyl)piperazin-1-yl)methyl)benzamide

: 1124213-72-4
3-((4-(4-amino-2-chlorobenzoyl)piperazin-1-yl)methyl)-N-tert-butylbenzamide

Guidance literature:: With hydrogenchloride; iron; In isopropyl alcohol; at 20 ℃; for 2h;

Reference yield:

: 1094362-66-9
N-tert-butyl-3-(chloromethyl)benzamide

: 1124213-72-4
3-((4-(4-amino-2-chlorobenzoyl)piperazin-1-yl)methyl)-N-tert-butylbenzamide

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 20 °C / Inert atmosphere

2: trifluoroacetic acid / dichloromethane / 2.5 h / 60 °C

3: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine / dichloromethane

4: hydrogenchloride; iron / isopropyl alcohol / 2 h / 20 °C

With hydrogenchloride; iron; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; dimethyl sulfoxide; isopropyl alcohol;

Reference yield:

: 63024-77-1
3-(Chloromethyl)benzoyl chloride

: 1124213-72-4
3-((4-(4-amino-2-chlorobenzoyl)piperazin-1-yl)methyl)-N-tert-butylbenzamide

Guidance literature:: Multi-step reaction with 5 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / -30 - 20 °C

2: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 20 °C / Inert atmosphere

3: trifluoroacetic acid / dichloromethane / 2.5 h / 60 °C

4: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine / dichloromethane

5: hydrogenchloride; iron / isopropyl alcohol / 2 h / 20 °C

With hydrogenchloride; iron; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; dimethyl sulfoxide; isopropyl alcohol;