5-benzyloxy-2-[1-(4-bromophenyl)cyclopentylmethyl]-6-hydroxypyrimidine-4-carboxylic acid (2-hydroxyethyl)isopropylamide

Base Information

Chemical Name:5-benzyloxy-2-[1-(4-bromophenyl)cyclopentylmethyl]-6-hydroxypyrimidine-4-carboxylic acid (2-hydroxyethyl)isopropylamide
CAS No.:1616924-26-5
Molecular Formula:C₂₉H₃₄BrN₃O₄
Molecular Weight:568.511
Hs Code.:

Synonyms:5-benzyloxy-2-[1-(4-bromophenyl)cyclopentylmethyl]-6-hydroxypyrimidine-4-carboxylic acid (2-hydroxyethyl)isopropylamide

Suppliers and Price of 5-benzyloxy-2-[1-(4-bromophenyl)cyclopentylmethyl]-6-hydroxypyrimidine-4-carboxylic acid (2-hydroxyethyl)isopropylamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 5-benzyloxy-2-[1-(4-bromophenyl)cyclopentylmethyl]-6-hydroxypyrimidine-4-carboxylic acid (2-hydroxyethyl)isopropylamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5-benzyloxy-2-[1-(4-bromophenyl)cyclopentylmethyl]-6-hydroxypyrimidine-4-carboxylic acid (2-hydroxyethyl)isopropylamide

There total 14 articles about 5-benzyloxy-2-[1-(4-bromophenyl)cyclopentylmethyl]-6-hydroxypyrimidine-4-carboxylic acid (2-hydroxyethyl)isopropylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1616924-25-4
5-benzyloxy-2-[1-(4-bromophenyl)cyclopentylmethyl]-6-hydroxypyrimidine-4-carboxylic acid [2-(tert-butyldimethylsilanyloxy)ethyl]isopropylamide

: 1616924-26-5
5-benzyloxy-2-[1-(4-bromophenyl)cyclopentylmethyl]-6-hydroxypyrimidine-4-carboxylic acid (2-hydroxyethyl)isopropylamide

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; water; at 20 ℃; for 1.5h;

Reference yield:

: 30379-55-6
benzyloxyacetic acid

: 1616924-26-5
5-benzyloxy-2-[1-(4-bromophenyl)cyclopentylmethyl]-6-hydroxypyrimidine-4-carboxylic acid (2-hydroxyethyl)isopropylamide

Guidance literature:: Multi-step reaction with 6 steps

1: thionyl chloride / 3 h / 0 - 20 °C

2: n-butyllithium; diisopropylamine / hexane; tetrahydrofuran / 2 h / -78 - 20 °C

3: sodium methylate / methanol / 16 h / 0 - 20 °C

4: lithium hydroxide monohydrate / tetrahydrofuran; water / 16 h / Reflux

5: pyridine; trichlorophosphate / 5 h / -10 °C

6: hydrogenchloride / tetrahydrofuran; water / 1.5 h / 20 °C

With pyridine; hydrogenchloride; n-butyllithium; thionyl chloride; lithium hydroxide monohydrate; sodium methylate; diisopropylamine; trichlorophosphate; In tetrahydrofuran; methanol; hexane; water;

Reference yield:

: 31600-43-8
methyl 2-(benzyloxy)acetate

: 1616924-26-5
5-benzyloxy-2-[1-(4-bromophenyl)cyclopentylmethyl]-6-hydroxypyrimidine-4-carboxylic acid (2-hydroxyethyl)isopropylamide

Guidance literature:: Multi-step reaction with 5 steps

1: n-butyllithium; diisopropylamine / hexane; tetrahydrofuran / 2 h / -78 - 20 °C

2: sodium methylate / methanol / 16 h / 0 - 20 °C

3: lithium hydroxide monohydrate / tetrahydrofuran; water / 16 h / Reflux

4: pyridine; trichlorophosphate / 5 h / -10 °C

5: hydrogenchloride / tetrahydrofuran; water / 1.5 h / 20 °C

With pyridine; hydrogenchloride; n-butyllithium; lithium hydroxide monohydrate; sodium methylate; diisopropylamine; trichlorophosphate; In tetrahydrofuran; methanol; hexane; water;