4-[1-(9-hydroxy-2-isopropyl-1,8-dioxo-1,3,4,8-tetrahydro-2H-pyrazino[1,2-c]pyrimidin-6-ylmethyl)cyclopentyl]benzonitrile

Base Information

Chemical Name:4-[1-(9-hydroxy-2-isopropyl-1,8-dioxo-1,3,4,8-tetrahydro-2H-pyrazino[1,2-c]pyrimidin-6-ylmethyl)cyclopentyl]benzonitrile
CAS No.:1616922-09-8
Molecular Formula:C₂₃H₂₆N₄O₃
Molecular Weight:406.484
Hs Code.:

Synonyms:4-[1-(9-hydroxy-2-isopropyl-1,8-dioxo-1,3,4,8-tetrahydro-2H-pyrazino[1,2-c]pyrimidin-6-ylmethyl)cyclopentyl]benzonitrile

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Chemical Property of 4-[1-(9-hydroxy-2-isopropyl-1,8-dioxo-1,3,4,8-tetrahydro-2H-pyrazino[1,2-c]pyrimidin-6-ylmethyl)cyclopentyl]benzonitrile

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Technology Process of 4-[1-(9-hydroxy-2-isopropyl-1,8-dioxo-1,3,4,8-tetrahydro-2H-pyrazino[1,2-c]pyrimidin-6-ylmethyl)cyclopentyl]benzonitrile

There total 13 articles about 4-[1-(9-hydroxy-2-isopropyl-1,8-dioxo-1,3,4,8-tetrahydro-2H-pyrazino[1,2-c]pyrimidin-6-ylmethyl)cyclopentyl]benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.53%

: 557-21-1
zinc(II) cyanide

: 1616924-27-6
9-benzyloxy-6-[1-(4-bromophenyl)cyclopentylmethyl]-2-isopropyl-3,4-dihydro-2H-pyrazino[1,2-c]pyrimidine-1,8-dione

: 1616922-09-8
4-[1-(9-hydroxy-2-isopropyl-1,8-dioxo-1,3,4,8-tetrahydro-2H-pyrazino[1,2-c]pyrimidin-6-ylmethyl)cyclopentyl]benzonitrile

Guidance literature:: With 1,1'-bis-(diphenylphosphino)ferrocene; bis(dibenzylideneacetone)-palladium⁽⁰⁾; zinc; In 1-methyl-pyrrolidin-2-one; at 120 ℃; for 16h; Sealed tube; Inert atmosphere;

Reference yield:

: N-(2-((tert-butyldimethylsilyl)oxy)ethyl)propan-2-amine

: 1616922-09-8
4-[1-(9-hydroxy-2-isopropyl-1,8-dioxo-1,3,4,8-tetrahydro-2H-pyrazino[1,2-c]pyrimidin-6-ylmethyl)cyclopentyl]benzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine; trichlorophosphate / 5 h / -10 °C

2: hydrogenchloride / tetrahydrofuran; water / 1.5 h / 20 °C

3: triphenylphosphine; diethylazodicarboxylate / dichloromethane / 2 h / 20 °C

4: bis(dibenzylideneacetone)-palladium⁽⁰⁾; zinc; 1,1'-bis-(diphenylphosphino)ferrocene / 1-methyl-pyrrolidin-2-one / 16 h / 120 °C / Sealed tube; Inert atmosphere

With pyridine; hydrogenchloride; 1,1'-bis-(diphenylphosphino)ferrocene; triphenylphosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; zinc; diethylazodicarboxylate; trichlorophosphate; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane; water;

Reference yield:

: 1616924-23-2
5-benzyloxy-2-[1-(4-bromophenyl)cyclopentylmethyl]-6-hydroxypyrimidine-4-carboxylic acid tert-butyl ester

: 1616922-09-8
4-[1-(9-hydroxy-2-isopropyl-1,8-dioxo-1,3,4,8-tetrahydro-2H-pyrazino[1,2-c]pyrimidin-6-ylmethyl)cyclopentyl]benzonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: lithium hydroxide monohydrate / tetrahydrofuran; water / 16 h / Reflux

2: pyridine; trichlorophosphate / 5 h / -10 °C

3: hydrogenchloride / tetrahydrofuran; water / 1.5 h / 20 °C

4: triphenylphosphine; diethylazodicarboxylate / dichloromethane / 2 h / 20 °C

5: bis(dibenzylideneacetone)-palladium⁽⁰⁾; zinc; 1,1'-bis-(diphenylphosphino)ferrocene / 1-methyl-pyrrolidin-2-one / 16 h / 120 °C / Sealed tube; Inert atmosphere

With pyridine; hydrogenchloride; 1,1'-bis-(diphenylphosphino)ferrocene; lithium hydroxide monohydrate; triphenylphosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; zinc; diethylazodicarboxylate; trichlorophosphate; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane; water;