4-[(3-chloro-6-cyano-benzo[b]thiophene-2-carbonyl)-amino]-benzoic acid methyl ester

Base Information

• Chemical Name: 4-[(3-chloro-6-cyano-benzo[b]thiophene-2-carbonyl)-amino]-benzoic acid methyl ester
• CAS No.: 849944-72-5
• Molecular Formula: C₁₈H₁₁ClN₂O₃S
• Molecular Weight: 370.816

Synonyms:4-[(3-chloro-6-cyano-benzo[b]thiophene-2-carbonyl)-amino]-benzoic acid methyl ester

Chemical Property of 4-[(3-chloro-6-cyano-benzo[b]thiophene-2-carbonyl)-amino]-benzoic acid methyl ester

Chemical Property:

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Technology Process of 4-[(3-chloro-6-cyano-benzo[b]thiophene-2-carbonyl)-amino]-benzoic acid methyl ester

There total 1 articles about 4-[(3-chloro-6-cyano-benzo[b]thiophene-2-carbonyl)-amino]-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.6%

3-Chlor-6-cyan-benzo--thiophen-2-carbonsaeurechlorid (75212-28-1) + 4-methoxycarbonyl aniline (619-45-4) → 4-[(3-chloro-6-cyano-benzo[b]thiophene-2-carbonyl)-amino]-benzoic acid methyl ester (849944-72-5)

Guidance literature:

With triethylamine; In tetrahydrofuran; for 2h; Heating;

DOI:10.1021/jm049541f

Reference yield:

4-[(3-chloro-6-cyano-benzo[b]thiophene-2-carbonyl)-amino]-benzoic acid methyl ester (849944-72-5) → 6-N''-isopropylamidino-N-(4'-carbmethoxyphenyl)-3-chlorobenzo[b]thiophene-2-carboxamide hydrochloride

Guidance literature:

Multi-step reaction with 2 steps

1: HCl(gas) / 720 h / 20 °C

2: 0.23 g / ethanol / 3 h / Heating

With hydrogenchloride; In ethanol;

DOI:10.1021/jm049541f

Reference yield:

4-[(3-chloro-6-cyano-benzo[b]thiophene-2-carbonyl)-amino]-benzoic acid methyl ester (849944-72-5) + ethanol (64-17-5) → 4-[(3-chloro-6-ethoxycarbonimidoyl-benzo[b]thiophene-2-carbonyl)-amino]-benzoic acid methyl ester; hydrochloride

Guidance literature:

With hydrogenchloride; at 20 ℃; for 720h;

DOI:10.1021/jm049541f

upstream raw materials:

3-Chlor-6-cyan-benzo--thiophen-2-carbonsaeurechlorid

4-methoxycarbonyl aniline

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