4-[(benzyloxycarbonyl)amino]-1-(tert-butyloxycarbonyl)piperidine-4-carboxylic acid tryptamide

Base Information

Chemical Name:4-[(benzyloxycarbonyl)amino]-1-(tert-butyloxycarbonyl)piperidine-4-carboxylic acid tryptamide
CAS No.:940290-02-8
Molecular Formula:C₂₉H₃₆N₄O₅
Molecular Weight:520.629
Hs Code.:

Synonyms:4-[(benzyloxycarbonyl)amino]-1-(tert-butyloxycarbonyl)piperidine-4-carboxylic acid tryptamide

Suppliers and Price of 4-[(benzyloxycarbonyl)amino]-1-(tert-butyloxycarbonyl)piperidine-4-carboxylic acid tryptamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-[(benzyloxycarbonyl)amino]-1-(tert-butyloxycarbonyl)piperidine-4-carboxylic acid tryptamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-[(benzyloxycarbonyl)amino]-1-(tert-butyloxycarbonyl)piperidine-4-carboxylic acid tryptamide

There total 7 articles about 4-[(benzyloxycarbonyl)amino]-1-(tert-butyloxycarbonyl)piperidine-4-carboxylic acid tryptamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 61-54-1
tryptamine

: 288154-16-5
4-(Benzyloxycarbonylamino)-1-(tert-butoxycarbonyl)-piperidine-4-carboxylic Acid

: 940290-02-8
4-[(benzyloxycarbonyl)amino]-1-(tert-butyloxycarbonyl)piperidine-4-carboxylic acid tryptamide

Guidance literature:: 4-(Benzyloxycarbonylamino)-1-(tert-butoxycarbonyl)-piperidine-4-carboxylic Acid; With chloroformic acid ethyl ester; triethylamine; In dichloromethane; at -20 ℃; for 1h;

tryptamine; With triethylamine; In dichloromethane; at 20 ℃; Further stages.;
DOI:10.1016/j.bmcl.2007.02.023

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 940290-02-8
4-[(benzyloxycarbonyl)amino]-1-(tert-butyloxycarbonyl)piperidine-4-carboxylic acid tryptamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 86 percent / Et₃N; DMAP / 1,2-dimethoxy-ethane / 20 °C

2.1: 76 percent / aq. NaOH / 1,2-dimethoxy-ethane / 48 h / 20 °C

3.1: 78 percent / K₂CO₃ / H₂O; dioxane / 20 °C

4.1: Et₃N; ethyl chloroformate / CH₂Cl₂ / 1 h / -20 °C

4.2: 67 percent / Et₃N / CH₂Cl₂ / 20 °C

With dmap; sodium hydroxide; chloroformic acid ethyl ester; potassium carbonate; triethylamine; In 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; water;
DOI:10.1016/j.bmcl.2007.02.023

Reference yield:

: 41979-39-9
4-piperidone hydrochloride

: 940290-02-8
4-[(benzyloxycarbonyl)amino]-1-(tert-butyloxycarbonyl)piperidine-4-carboxylic acid tryptamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: 75 percent / methanol; H₂O / 72 h / 20 °C

2.1: 86 percent / Et₃N; DMAP / 1,2-dimethoxy-ethane / 20 °C

3.1: 76 percent / aq. NaOH / 1,2-dimethoxy-ethane / 48 h / 20 °C

4.1: 78 percent / K₂CO₃ / H₂O; dioxane / 20 °C

5.1: Et₃N; ethyl chloroformate / CH₂Cl₂ / 1 h / -20 °C

5.2: 67 percent / Et₃N / CH₂Cl₂ / 20 °C

With dmap; sodium hydroxide; chloroformic acid ethyl ester; potassium carbonate; triethylamine; In 1,4-dioxane; methanol; 1,2-dimethoxyethane; dichloromethane; water;
DOI:10.1016/j.bmcl.2007.02.023