5-(3-chloromethyl-4-diphenylmethoxycarbonylceph-3-em-7β-yl)-dihydro-1,3,5-dioxazine

Base Information

Chemical Name:5-(3-chloromethyl-4-diphenylmethoxycarbonylceph-3-em-7β-yl)-dihydro-1,3,5-dioxazine
CAS No.:127092-37-9
Molecular Formula:C₂₄H₂₃ClN₂O₅S
Molecular Weight:486.976
Hs Code.:

Synonyms:5-(3-chloromethyl-4-diphenylmethoxycarbonylceph-3-em-7β-yl)-dihydro-1,3,5-dioxazine

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Chemical Property of 5-(3-chloromethyl-4-diphenylmethoxycarbonylceph-3-em-7β-yl)-dihydro-1,3,5-dioxazine

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Technology Process of 5-(3-chloromethyl-4-diphenylmethoxycarbonylceph-3-em-7β-yl)-dihydro-1,3,5-dioxazine

There total 1 articles about 5-(3-chloromethyl-4-diphenylmethoxycarbonylceph-3-em-7β-yl)-dihydro-1,3,5-dioxazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 79349-53-4
(6R,7R)-7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxyli acid diphenylmethyl ester hydrochloride

: 127092-37-9
5-(3-chloromethyl-4-diphenylmethoxycarbonylceph-3-em-7β-yl)-dihydro-1,3,5-dioxazine

Guidance literature:: With sodium hydroxide; In dichloromethane; water; for 2h; Ambient temperature; 20 equiv. of formalin;
DOI:10.1016/0040-4039(94)88521-4

Reference yield:

: 127092-37-9
5-(3-chloromethyl-4-diphenylmethoxycarbonylceph-3-em-7β-yl)-dihydro-1,3,5-dioxazine

: diphenylmethyl 7β-amino-3-vinylceph-3-em-4-carboxylate hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) PPh₃, NaI, 2.) 1N NaOH (pH 8-9) / 1.) N,N-dimethylacetamide, 1 h, 2.) CH₂Cl₂, 2 h

2: 92 percent / 6N HCl / CH₂Cl₂ / 1 h

With hydrogenchloride; sodium hydroxide; triphenylphosphine; sodium iodide; In dichloromethane;
DOI:10.1016/0040-4039(94)88521-4

Reference yield:

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 127092-37-9
5-(3-chloromethyl-4-diphenylmethoxycarbonylceph-3-em-7β-yl)-dihydro-1,3,5-dioxazine

: 127092-39-1
5-(4-diphenylmethoxycarbonyl-3-vinylceph-3-em-7β-yl)-dihydro-1,3,5-dioxazine

Guidance literature:: With sodium hydroxide; triphenylphosphine; sodium iodide; Yield given. Multistep reaction; 1.) N,N-dimethylacetamide, 1 h, 2.) CH₂Cl₂, 2 h;
DOI:10.1016/0040-4039(94)88521-4