(±)-8-aminooctanoic acid 2,5,7,8-tetramethyl-2-[4-(3-methyl-2,4-dioxothiazolidin-(5Z)-ylidenemethyl)phenoxymethyl]chroman-6-yl ester trifluoroacetic acid salt

Base Information

Chemical Name:(±)-8-aminooctanoic acid 2,5,7,8-tetramethyl-2-[4-(3-methyl-2,4-dioxothiazolidin-(5Z)-ylidenemethyl)phenoxymethyl]chroman-6-yl ester trifluoroacetic acid salt
CAS No.:1448960-21-1
Molecular Formula:C₂HF₃O₂*C₃₃H₄₂N₂O₆S
Molecular Weight:708.796
Hs Code.:

(±)-8-aminooctanoic acid 2,5,7,8-tetramethyl-2-[4-(3-methyl-2,4-dioxothiazolidin-(5Z)-ylidenemethyl)phenoxymethyl]chroman-6-yl ester trifluoroacetic acid salt

Synonyms:(±)-8-aminooctanoic acid 2,5,7,8-tetramethyl-2-[4-(3-methyl-2,4-dioxothiazolidin-(5Z)-ylidenemethyl)phenoxymethyl]chroman-6-yl ester trifluoroacetic acid salt

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Chemical Property of (±)-8-aminooctanoic acid 2,5,7,8-tetramethyl-2-[4-(3-methyl-2,4-dioxothiazolidin-(5Z)-ylidenemethyl)phenoxymethyl]chroman-6-yl ester trifluoroacetic acid salt

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Technology Process of (±)-8-aminooctanoic acid 2,5,7,8-tetramethyl-2-[4-(3-methyl-2,4-dioxothiazolidin-(5Z)-ylidenemethyl)phenoxymethyl]chroman-6-yl ester trifluoroacetic acid salt

There total 4 articles about (±)-8-aminooctanoic acid 2,5,7,8-tetramethyl-2-[4-(3-methyl-2,4-dioxothiazolidin-(5Z)-ylidenemethyl)phenoxymethyl]chroman-6-yl ester trifluoroacetic acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 1448960-22-2
(±)-8-tert-butoxycarbonylamino-octanoic acid 2,5,7,8-tetramethyl-2-[4-(3-methyl-2,4-dioxothiazolidin-(5Z)-ylidenemethyl)phenoxymethyl]chroman-6-yl ester

: 76-05-1
trifluoroacetic acid

: 1448960-21-1
(±)-8-aminooctanoic acid 2,5,7,8-tetramethyl-2-[4-(3-methyl-2,4-dioxothiazolidin-(5Z)-ylidenemethyl)phenoxymethyl]chroman-6-yl ester trifluoroacetic acid salt

Guidance literature:: In dichloromethane; at 20 ℃; for 3h;
DOI:10.1016/j.ejmech.2014.06.015

Reference yield:

: 1375483-19-4
8-tert-butoxycarbonylamino-octanoic acid 2-{4-[2,4-dioxo-thiazolidin-(5Z)-ylidenemethyl]-phenoxymethyl}-2,5,7,8-tetramethyl-chroman-6-yl ester

: 1448960-21-1
(±)-8-aminooctanoic acid 2,5,7,8-tetramethyl-2-[4-(3-methyl-2,4-dioxothiazolidin-(5Z)-ylidenemethyl)phenoxymethyl]chroman-6-yl ester trifluoroacetic acid salt

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 80 °C / Inert atmosphere

2: dichloromethane / 3 h / 20 °C

With potassium carbonate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2014.06.015

Reference yield:

: (5Z)-5-[1-[4-(6-hydroxy-2,5,7,8-tetramethylchroman-2-ylmethoxy)phenyl]methylylidene]thiazolidine-2,4-dione

: 1448960-21-1
(±)-8-aminooctanoic acid 2,5,7,8-tetramethyl-2-[4-(3-methyl-2,4-dioxothiazolidin-(5Z)-ylidenemethyl)phenoxymethyl]chroman-6-yl ester trifluoroacetic acid salt

Guidance literature:: Multi-step reaction with 3 steps

1.1: isobutyl chloroformate; triethylamine / dichloromethane / 1 h / Inert atmosphere

1.2: 12 h / 20 °C / Inert atmosphere

2.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 80 °C / Inert atmosphere

3.1: dichloromethane / 3 h / 20 °C

With potassium carbonate; triethylamine; isobutyl chloroformate; In dichloromethane; N,N-dimethyl-formamide;