(±)-8-tert-butoxycarbonylamino-octanoic acid 2,5,7,8-tetramethyl-2-[4-(3-methyl-2,4-dioxothiazolidin-(5Z)-ylidenemethyl)phenoxymethyl]chroman-6-yl ester

Base Information

Chemical Name:(±)-8-tert-butoxycarbonylamino-octanoic acid 2,5,7,8-tetramethyl-2-[4-(3-methyl-2,4-dioxothiazolidin-(5Z)-ylidenemethyl)phenoxymethyl]chroman-6-yl ester
CAS No.:1448960-22-2
Molecular Formula:C₃₈H₅₀N₂O₈S
Molecular Weight:694.89
Hs Code.:

(±)-8-tert-butoxycarbonylamino-octanoic acid 2,5,7,8-tetramethyl-2-[4-(3-methyl-2,4-dioxothiazolidin-(5Z)-ylidenemethyl)phenoxymethyl]chroman-6-yl ester

Synonyms:(±)-8-tert-butoxycarbonylamino-octanoic acid 2,5,7,8-tetramethyl-2-[4-(3-methyl-2,4-dioxothiazolidin-(5Z)-ylidenemethyl)phenoxymethyl]chroman-6-yl ester

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Chemical Property of (±)-8-tert-butoxycarbonylamino-octanoic acid 2,5,7,8-tetramethyl-2-[4-(3-methyl-2,4-dioxothiazolidin-(5Z)-ylidenemethyl)phenoxymethyl]chroman-6-yl ester

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Technology Process of (±)-8-tert-butoxycarbonylamino-octanoic acid 2,5,7,8-tetramethyl-2-[4-(3-methyl-2,4-dioxothiazolidin-(5Z)-ylidenemethyl)phenoxymethyl]chroman-6-yl ester

There total 3 articles about (±)-8-tert-butoxycarbonylamino-octanoic acid 2,5,7,8-tetramethyl-2-[4-(3-methyl-2,4-dioxothiazolidin-(5Z)-ylidenemethyl)phenoxymethyl]chroman-6-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1375483-19-4
8-tert-butoxycarbonylamino-octanoic acid 2-{4-[2,4-dioxo-thiazolidin-(5Z)-ylidenemethyl]-phenoxymethyl}-2,5,7,8-tetramethyl-chroman-6-yl ester

: 74-88-4
methyl iodide

: 1448960-22-2
(±)-8-tert-butoxycarbonylamino-octanoic acid 2,5,7,8-tetramethyl-2-[4-(3-methyl-2,4-dioxothiazolidin-(5Z)-ylidenemethyl)phenoxymethyl]chroman-6-yl ester

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 4h; Inert atmosphere;
DOI:10.1016/j.ejmech.2014.06.015

Reference yield:

: (5Z)-5-[1-[4-(6-hydroxy-2,5,7,8-tetramethylchroman-2-ylmethoxy)phenyl]methylylidene]thiazolidine-2,4-dione

: 1448960-22-2
(±)-8-tert-butoxycarbonylamino-octanoic acid 2,5,7,8-tetramethyl-2-[4-(3-methyl-2,4-dioxothiazolidin-(5Z)-ylidenemethyl)phenoxymethyl]chroman-6-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: isobutyl chloroformate; triethylamine / dichloromethane / 1 h / Inert atmosphere

1.2: 12 h / 20 °C / Inert atmosphere

2.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 80 °C / Inert atmosphere

With potassium carbonate; triethylamine; isobutyl chloroformate; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 30100-16-4
8-tert-butoxycarbonylaminooctanoic acid

: 1448960-22-2
(±)-8-tert-butoxycarbonylamino-octanoic acid 2,5,7,8-tetramethyl-2-[4-(3-methyl-2,4-dioxothiazolidin-(5Z)-ylidenemethyl)phenoxymethyl]chroman-6-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: isobutyl chloroformate; triethylamine / dichloromethane / 1 h / Inert atmosphere

1.2: 12 h / 20 °C / Inert atmosphere

2.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 80 °C / Inert atmosphere

With potassium carbonate; triethylamine; isobutyl chloroformate; In dichloromethane; N,N-dimethyl-formamide;