5-((((4S,5S,6R)-5-chloro-2,2-dimethyl-6-((S)-1,1,4-trichloro-4-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)butyl)-1,3-dioxan-4-yl)methyl)thio)-1-phenyl-1H-tetrazole

Base Information

Chemical Name:5-((((4S,5S,6R)-5-chloro-2,2-dimethyl-6-((S)-1,1,4-trichloro-4-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)butyl)-1,3-dioxan-4-yl)methyl)thio)-1-phenyl-1H-tetrazole
CAS No.:1333237-39-0
Molecular Formula:C₂₃H₃₀Cl₄N₄O₄S
Molecular Weight:600.394
Hs Code.:

Synonyms:5-((((4S,5S,6R)-5-chloro-2,2-dimethyl-6-((S)-1,1,4-trichloro-4-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)butyl)-1,3-dioxan-4-yl)methyl)thio)-1-phenyl-1H-tetrazole

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Chemical Property of 5-((((4S,5S,6R)-5-chloro-2,2-dimethyl-6-((S)-1,1,4-trichloro-4-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)butyl)-1,3-dioxan-4-yl)methyl)thio)-1-phenyl-1H-tetrazole

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Technology Process of 5-((((4S,5S,6R)-5-chloro-2,2-dimethyl-6-((S)-1,1,4-trichloro-4-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)butyl)-1,3-dioxan-4-yl)methyl)thio)-1-phenyl-1H-tetrazole

There total 11 articles about 5-((((4S,5S,6R)-5-chloro-2,2-dimethyl-6-((S)-1,1,4-trichloro-4-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)butyl)-1,3-dioxan-4-yl)methyl)thio)-1-phenyl-1H-tetrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1333237-38-9
((4S,5S,6R)-5-chloro-2,2-dimethyl-6-((S)-1,1,4-trichloro-4-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)butyl)-1,3-dioxan-4-yl)methanol

: 86-93-1
1-Phenyl-1H-tetrazole-5-thiol

: 1333237-39-0
5-((((4S,5S,6R)-5-chloro-2,2-dimethyl-6-((S)-1,1,4-trichloro-4-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)butyl)-1,3-dioxan-4-yl)methyl)thio)-1-phenyl-1H-tetrazole

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 20 ℃; for 1h; Inert atmosphere;
DOI:10.1021/jacs.9b05013

Reference yield:

: 1333237-36-7
(2S,3S)-6-((4R,5S,6S)-6-((benzyloxy)methyl)-5-chloro-2,2-dimethyl-1,3-dioxan-4-yl)-3,6,6-trichlorohexane-1,2-diol

: 1333237-39-0
5-((((4S,5S,6R)-5-chloro-2,2-dimethyl-6-((S)-1,1,4-trichloro-4-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)butyl)-1,3-dioxan-4-yl)methyl)thio)-1-phenyl-1H-tetrazole

Guidance literature:: Multi-step reaction with 3 steps

1: toluene-4-sulfonic acid; copper(II) sulfate / 20 h / 20 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / ethyl acetate / 2 h / 20 °C / 760.05 Torr

3: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

With di-isopropyl azodicarboxylate; palladium 10% on activated carbon; hydrogen; toluene-4-sulfonic acid; copper(II) sulfate; triphenylphosphine; In tetrahydrofuran; ethyl acetate; 3: Mitsunobu reaction;
DOI:10.1002/anie.201102521

Reference yield:

: 1333237-37-8
(4S,5S,6R)-4-((benzyloxy)methyl)-5-chloro-2,2-dimethyl-6-((S)-1,1,4-trichloro-4-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)butyl)-1,3-dioxane

: 1333237-39-0
5-((((4S,5S,6R)-5-chloro-2,2-dimethyl-6-((S)-1,1,4-trichloro-4-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)butyl)-1,3-dioxan-4-yl)methyl)thio)-1-phenyl-1H-tetrazole

Guidance literature:: Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 2 h / 20 °C / 760.05 Torr

2: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

With di-isopropyl azodicarboxylate; palladium 10% on activated carbon; hydrogen; triphenylphosphine; In tetrahydrofuran; ethyl acetate; 2: Mitsunobu reaction;
DOI:10.1002/anie.201102521